Abstract: The aim of this study was to evaluate the hepatoprotective effect of turmeric extract of Curcuma longa on carbon tetrachloride induced hepatotoxicity in male rats. The hepatoprotective activity was assessed using various biochemical parameters like lipid profile, Liver enzymes, antioxidant enzymes and histological examinations of the liver were also carried out. Forty-five males rats (Westar strain) weighing approximately 175-205 g were divided into five groups. Each consisted of nine rats as follows: Group A: healthy control rats) subjected to 1ml olive oil administration orally using gastric tube daily for 4 weeks. The rats of Group B, Group C, Group D and Group E were injected with Carbon tetrachloride (0.1 mL/ 100 g body weight) dissolved in olive oil [1:1(v/v)] twice weekly in the first day and fourth day every week for four weeks. Group B: Hepatotoxic control rats (positive control rats....
Key words Turmeric extract, hepatoprotective effect, lipid profile, Liver enzymes, antioxidant enzymes, histological examinations
[1]. Akindele, A. J., Ezenwanebe, K. O ,Anunobi, C. C., and Adeyemi, O. O. 2010. Hepatoprotective and in vivo antioxidant effects of Byrsocarpuscoccineus Schum.andThonn.(Connaraceae). J Ethnopharmacol,129,46–52.
[2]. Ali, H., Kabir, N., Muhammad, A., Shah, M. R., Musharraf, S. G. and Iqbal, N. 2014.Hautriwaic acid as one of the hepatoprotective constituent of Dodonaeaviscosa.Phytomedicine , 21, 131–140.
[3]. Anand, P.,Thomas, S.G., Kunnumakkara, A.B., Sundaram, C., Harikumar, K.B., Sung, B., Tharakan, S.T. and Misrs, K. 2008. Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature. Biochem.Pharmacol., 11,1590-1611.
[4]. Arafa, M. 2005. Curcumin attenuates diet-induced hypercholesterolemia in rats. Journal of pharmacy and pharmacology, 11,228-234.
[5]. Armendariz-Borunda, J., Katai, H., Jones, C. M., Seyer, J. M., Kang, A. H., and Raghow, R. (1993):Transforming growth factor beta gene expression is transiently enhanced at a critical stage during liver regeneration after CCl4 treatment. Lab Invest, 3.283-294