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| Paper Type | : | Research Paper |
| Title | : | Acute Toxicity and In Vivo Hepatoprotective And Nephroprotective Inethanol Extract Ofgmelina Arborea and Grewia Umbellifera |
| Country | : | India |
| Authors | : | Sakthivel .S || Sheik Abdulla.S |
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: | 10.9790/3008-1204030127  |
Abstract: The present study was carried out the effect of Gmelina arborea and Grreia umbellifera in nephroprotective and hepatoprotective of the selected plant. The plant has analyzed the primary phytochemical and Gas chromatography and mass spectroscopic to find the active components, then the plant where selected the further investigation. The selected plant have protective effect has proved the analyzed liver enzymes and kidney markers in that result are demonstrated in this paper detailed.The results of the present investigation infer that these plants (GA and GU) extractspossess potent antioxidant, Hepatoprotective and nephroprotective property, the former being probably responsiblethan the later. Thus, the extracts can be beneficial in treating liver and renal damages caused due to chemical exposure..
Keywords: Gmelina arborea, Grewia umbellifera, ALT,-D Glucorinidase, -D galactoridase, ALT, GGT
[1] Ashis G. Herbal folk remedies of Bankura and Medinipur districts, West Bengal. Indian Journal of Traditional Knowledge 2003; 2:393-396.
[2] SenthamilSelvan palanivelu and Velavan "Analysis of bioactive compounds in ethanol extracts Argemone mexicane plant seeds using GC-MS techniques"Indian journal of applied research2015; 5:5; 19-20.
[3] SenthamilSelvan palanivelu and Velavan "Analysis of phytochemical component and nutrients component in ethanol extracted oldenlandia corymbosa"World Journal of Pharmaceutical Research 2015; 4:7; 1965 - 1967.
[4] SenthamilSelvan palanivelu "Anti-hyperlipidemic activity of the bark extract of terminalia arjuna in caffeine induced mice"indian journal of applied research2015; 5:8; 310 - 313.
[5] Baris O, Gulluce M, Sahin F, Ozer H, Kilic H, Ozkan H, Sokmen M and Ozbek T, 2006. Biological activities of the essential oil and methanolextract ofAchilleaBiebersteiniiAfan. (Asteraceae).Turk. J. Biol., 30: 65–73.
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| Paper Type | : | Research Paper |
| Title | : | Plant Regeneration from Nodal explants Culture through Organogenesis in Eupatorium triplinerve vahl |
| Country | : | India |
| Authors | : | S.Usha || Karpagam, S |
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: | 10.9790/3008-1204032832 |
Abstract: An efficient plant regeneration protocol was developed for Eupatorium triplinerve Vahl, an important medicinal herb. Nodal explants inoculated on Murashige and Skoog medium supplemented with 4.44 μM 6-Benzyladenine(BA), showed better growth response and produced 18.3±1.15 number of shoots per explant with an average length of 6.4± 0.06 cm after 30 days. Rooting of shoots was achieved in half strength MS medium supplemented with 2.46 μM Indol-3-butyric acid, this produced 6.02 ± 0.2 number of roots per shoot with an average height of 3.5 ± 0.1 cm after 30 days. The rooted plantlets were transferred in the pots hardening, 80 percent of plantlets survived and resumed growth in the mixture of soil, vermiculite and farm yard manure (1 : 1 : 1).
Keywords: Eupatorium triplinerve, Nodal explants, Invitro tissue culture, Plant regeneration
[1]. K.P. Martin. Rapid axillary bud proliferation and ex vitro rooting of Eupatorium triplinerve. 47, Biologia Plantarum, 2003, 589-591,
[2]. A. Ghani,. Medicinal plants of Bangladesh : Chemical constituents and uses. ( 1st edn. Asiatic Society of Bangladesh. 1998) (174).
[3]. S. Rahman, and M.Junaid, Antimicrobial activity of leaf extracts of Eupatorium triplinerve vehl. against some human pathogenic bacteria and phytopathogenic fungi. 37(1), Bangladesh J. Bot. 2008, 89-92.
[4]. T. Murashige, F. Skoog. A revised medium for rapid growth and bioassay with tobacco tiss..cult. 15, Physiol.Plant. 1962, 473-479.
[5]. P.V Pattar, and M Jayara. In vitro plant regeneration of Plantlets from Leaf and Nodal explants of Aristolochia indica L.- An Important Threatened Medicinal Plant.1691(12), Asian Paci. J Trop. Biomed. 2012, 60257-60259.
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| Paper Type | : | Research Paper |
| Title | : | Mini Review: Antitumor promotion as the best strategy for chemoprevention |
| Country | : | Malaysia |
| Authors | : | Mohd Rohaizad Md Roduan |
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: | 10.9790/3008-1204033342 |
Abstract: Transformation of normal cell to cancer cell is known to be a multiple step process known as carcinogenesis. A lot of chemopreventive agents have been isolated from plant derived phytocompound reported to exhibit potent anticancer activity in many cancer models in vitro and in vivo as they can inhibit the crucial process during carcinogenesis. Carcinogenesis comprises of three stages, namely initiation, promotion and progression. Due to multistep process of carcinogenesis............
Keywords: Anticancer, carcinogenesis, chemoprevention, proliferation, promotion
[1] S. Manoharan, R.B. Singh, and S. Balakrishnan, Chemopreventive Mechanisms of Natural Products in Oral, Mammary and Skin Carcinogenesis: An Overview, The Open Nutraceuticals Journal, 2(1), 2009, 52-63.
[2] D. Hanahan, and R.A. Weinberg, Hallmark of cancer, in J.K David et al, (Ed.), Oxford Textbook of Oncology 3, (Kettering, UK: Oxford University Press, 2016) 3-10.
[3] J.M. Cullen, R. Page, and W. Misdorp, in J.M. Donald, An Overview of Cancer Pathogenesis, Diagnosis, and Management, (Iowa: Iowa State Press, 2008) 1-44.
[4] J.E. Rundhaug, and S.M. Fischer, Molecular Mechanisms of Mouse Skin Tumor Promotion. Cancers, 2(2), 2010, 436-482.
[5] B. Alberts, A. Johnson, J. Lewis, M. Raff, K. Roberts, and P. Walter, Molecular biology of the cell. (New York: Garland Science, 2002)..
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| Paper Type | : | Research Paper |
| Title | : | Using Box–Wilson statistical design to optimize biodegradation of phenanthrene and generation of sustainable power in microbial fuel cell simultaneously |
| Country | : | Saudi Arabia. |
| Authors | : | Alshehri A.N.Z. |
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: | 10.9790/3008-1204034359 |
Abstract: Microbial Fuel Cells (MFCs) are increasingly being used as a source of sustainable energy, as this technology can generate bioelectricity from the chemical energy present in organic pollutants. This potential was demonstrated in this study using the toxic and highly resistant polycyclic aromatic hydrocarbon by degrading as substrate in MFC. Optimization of the phenanthrene biodegradation and the resultant power generation in MFC was made by applying the Box-Wilson Statistical Design (BWSD) with the following six as parameters: (1) phenanthrene degradation, (2) voltage, (3) power density, (4) current density, (5) coulombic efficiency, and (6) COD removal. Optimization.............
Keywords: Box–Wilson statistical design/ Biodegradation/ Microbial fuel cell, Phenanthrene/ Sustainable power.
[1]. Adelaja O.A., Keshavarz T., Kyazze G. (2014) Enhanced biodegradation of phenanthrene using different inoculum types in a microbial fuel cell, Eng. in Life Sci. 14: 218–228.
[2]. Adour L., Arbia W., Amrane A., Mameri N. (2008) Combined use of waste materials-recovery of chitin from shrimp shells by lactic acid fermentation supplemented with date juice waste or glucose. J. Chem. Tech. Biotech. 83: 1664-1669.
[3]. Akhir S.M., Abd-Aziz S., Salleh M.M., Rahman R.A., Illia R.M., Hassan M.A. (2009) Medium optimization of chitinase enzyme production from shrimp waste using Bacillus licheniformisTH-1 by response surface methods. Biotechnol. 8(1): 120-125.
[4]. Al-Ahmadi K.J., Yazdi M.T., Najafi M.F., Shahverdi A.R. (2008) Optimization of medium and cultivation conditions for chitinase production by the newly isolated Aeromonassp. Biotechnol. 7(2): 266-272.
[5]. Alalayah W.M., Kalil M.S., Kadhum A.A.H., Jahim J., Zaharim A., Alauj N.M., El Shafie A. (2010) Applications of the Box-Wilson Design model for bio-hydrogen production using Clostridium saccharoperbutylacetonicum N1-4(ATCC13564). Pak. J. of Biol. Sci. 13(14): 674 – 682.
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| Paper Type | : | Research Paper |
| Title | : | Studies on Micromorphological Taxonomic Variations in Abutilon Species of Indian Thar Desert |
| Country | : | India |
| Authors | : | Ilham Bano || G.S.Deora |
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: | 10.9790/3008-1204036068 |
Abstract: Micromorphological taxonomic variations of leaves in three common species of genus Abutilon Mill.viz. Abutilon indicum(Linn.) Sweet,Abutilon pannosum (Forst.f.) Schlect. and Abutilon ramosum (Cav.) Guill. and Perr. in Indian Thar desert were studied and its taxonomic relevance for identification and delineation of species were evaluated. Leaves were amphistomatic and amphitrichomic while stomata and trichomes were more concentrated on abaxial leaf surface. Both anomocytic and anisocytic stomata were reported. Epidermal cells on adaxial leaf surface were polygonal with straight wall pattern while on abaxial leaf surface irregular shaped epidermal cells with undulating wall pattern were observed..............
Keywords: Taxonomic variations, Leaf micromorphology, Abutilon, Trichomes, Peltate glands, Bifurcated trichome.
[1] Miller,P.,1754.The Gardeners Dictionary 3:23.John and James Rivington, London.
[2] Sweet, R., 1826. Hortusbritannicus,ed.1. London.
[3] Kearney, T.H., 1958. A tentative key to the South American species of Abutilon.Leafl. W. Bot. 8: 201-
216.
[4] Fryxell, P.A., 1979. The American genera of Malvaceae-II.Brittonia 49:204-269.
[5] Sivarajan, V.V. and Pradeep, A.K., 1996. Malvaceae of Southern Peninsular India: A taxonomic
monograph, Daya Publ. House, Delhi:201–204.
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| Paper Type | : | Research Paper |
| Title | : | Development and Validation of a Simple, Sensitive, Selective and Stability-Indicating RP-HPLC Method for the Determination of Darunavir and Cobicistat in pharmaceutical combined dosage forms |
| Country | : | India |
| Authors | : | Mathews Bommella || R.N.Rao || Mukkanti Khagga || Sarbani Pal |
|
: | 10.9790/3008-1204036978 |
Abstract:The study describes development and subsequent validation of a stability indicating reverse-phase HPLC method for simultaneous estimation of the Darunavir and Cobicistat in combined Pharmaceutical dosage form using RP-HPLC. Separation was accomplished on BDS 250 x 4.6 mm, 5m C18 column using 0.1% Perchloric acid buffer and acetonitrile (38:62 v/v) as mobile phase pumped through at a flow rate of 1 ml/min at 30°C. Optimized wavelength was 211 nm, retention time of Darunavir and Cobicistat were found to be 2.24 min and 2.63 min respectively. % RSD of the Darunavir and Cobicistat were found to be 0.3 and 0.5 respectively. Mean recovery were found to be 100.0% and 100.04% for Darunavir and Cobicistat respectively. The proposed method also proved to be suitable as a rapid and reliable quality control method.
Keywords: Darunavir, Cobicistat, RP-HPLC, Simultaneous determination, Degradation studies.
[1] McKeage K, Perry CM and Keam SJ. Darunavir: a review of its use in the management of HIV infection in adults, Drugs, 69(4),
2009, 477-503.
[2] Ghosh AK, Dawson ZL and Mitsuya H. Darunavir, a conceptually new HIV-1 protease inhibitor for the treatment of drug-resistant
HIV. Bioorganic and Medicinal Chemistry, 15(24), 2007, 7576-7580.
[3] Shah BM, Schafer JJ, Priano J, Squires KE: Cobicistat: a new boost for the treatment of human immunodeficiency virus infection.
Pharmacotherapy, 33, 2013, 1107–1116.
[4] Back D , Sekar V , Hoetelmans RM, Darunavir: pharmacokinetics and drug interactions, Antiviral Theraphy, 13(1), 2008, 1-13
[5] Xu L, Liu H, Murray B, Callebaut C, Lee MS, Hong A, Strickley RG, Tsai LK, Stray KM, Wang Y, Rhodes GR, Desai MC:
Cobicistat (GS-9350): a potent and selective inhibitor of human CYP 3A as a novel pharmacoenhancer. ACS Med Chem Lett, 1,
2010, 209–213.
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| Paper Type | : | Research Paper |
| Title | : | Knowledge, Attitude and Practice of standard precaution among Health Care Workers in Federal Medical Centre Yenagoa, Nigeria |
| Country | : | Nigeria |
| Authors | : | Agofure Otovwe || Perewari O. Adidatimi |
|
: | 10.9790/3008-1204037986 |
Abstract:Background: Health care workers (HCWs) are at a high risk of needle stick injuries and blood borne pathogens, such as HIV, and Hepatitis B and C viruses, as they perform their clinical activities in the hospital. Objectives: This study was therefore designed to determine the knowledge, attitude and practice of standard precautions among HCWs in Federal Medical Centre Yenagoa Bayelsa State, Nigeria. Methodology: This is a cross-sectional study carried out among 200 health workers at Federal Medical Centre Yenagoa, Bayelsa State. They were selected through a stratified sampling technique. The instrument used for data collection was a semi-structured questionnaire that assessed the knowledge, attitude and practice of standard precautions...........
Keywords: Standard precautions, knowledge, attitude, practice, blood-borne infection, needle stick injury, health care workers, compliance
[1] Tobin EA, Asogun DA, Odia I, Ehidiamhen G. Knowledge and practice of infection control among health workers in a tertiary hospital in Edo state, Nigeria. Direct Res J Health Pharm 2013; 1(2):20-27.
[2] Foster TM, Lee MG, McGaw CD, Frankson MA. Knowledge and practice of occupational infection control among health care workers in Jamaica. West Indian Med J 2010; 59 (2):147-152.
[3] Jahan S. Epidemiology of needle stick injuries among health care workers in a secondary care hospital in Saudi Arabia. Ann Saudi Med 2005; 25(3):233-238.
[4] Amoran OE, Onwube OO. Infection Control and Practice of Standard Precautions among Healthcare Workers in Northern Nigeria. J Glob Infect Dis 2013; 5(4):156–163.
[5] Worker Health Chart book. Blood borne Infections and Percutaneous Exposures DHHS (NIOSH) Publication No. 2004:146.
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| Paper Type | : | Research Paper |
| Title | : | Effect of Additive Tamoxifen Citrate to SMART Medium on Human Sperm Parameters during In vitro Sperm Activation |
| Country | : | Iraq |
| Authors | : | Noor Kareem Kadhim || Jabaar H. Yenzeel || Muhammed-Baqir M-R Fakhrildin |
|
: | 10.9790/3008-1204038791 |
Abstract: This study was aimed to investigate the effect of addition of tamoxifen citrate on the outcome of in vitro human sperm activation. One hundred semen samples for fertile and infertile men were randomly collected from the subjects at the High Institute for Infertility Diagnosis and Assisted Reproductive Technologies / Al- Nahrain University. The mean age was (32.21± 0.83) years and mean duration of infertility was (5.26 ± 0.41) years. Before using centrifugation swim-up technique, the washed samples were divided into three groups: control group (G1) without tamoxifen citrate, while in the second(G2) and third(G3) group, two concentrations oftamoxifen citrate (20μg/mL and 40μg/mL)..........
Keywords: Tamoxifen citrate, SMART medium, in vitro sperm activation.
[1] World Health Organization (WHO) 2010.WHO laboratory manual for the examination of human semen and semen-cervical mucus interaction.5th edition. Cambridge: Cambridge University Press. pp: 162-224.
[2] Ye, H.; Huang, G. N.; Gao, Y. and Liu, D. Y. 2006.Relationship between human sperm-hyaluronan binding assay and fertilization rate in conventional in vitro fertilization.Hum. Reprod. 6: 1545¬˗1550.
[3] Agarwal, A. and Sharma, R. K. 2007.Automation is the key to standardized semen analysis using the automated SQA-V sperm quality analyzer. Fertil.Steril., 87: 156-162.
[4] Ravnik SE, Zarutskie PW, Muller CH. 1992.Purification and characterization of a human follicular fluid, lipid transfer protein that stimulates human capacitation. BiolReprod; 47: 1126–33.
[5] Adamopoulos, D. A.; Pappa, A.; Billa, E.; Nicopoulous, S.; Eftychia K. 2003.Effectiveness of combined tamoxifen and testosterone treatment in men with idiopathic oligospermia. Fert.Steril., 80: 914-920.