iosr-JDMS   Volume-24 ~ Issue-6 ~ June 2025

Abstract: Résumé : Les métastases osseuses de la main et des pieds ou acrométastases sont extrêmement rares et apparaissent majoritairement dans le contexte de cancer pulmonaire. Leur présentation clinique, souvent trompeuse, peut simuler une pathologie inflammatoire, retardant ainsi le diagnostic étiologique. Nous rapportons le cas d’un patient présentant une tuméfaction douloureuse du pouce droit, chez qui le bilan d’imagerie et l’étude histologique ont révélé une acrométastase révélatrice d’un adénocarcinome bronchique. Cette observation souligne l’importance d’évoquer une origine néoplasique devant toute atteinte osseuse périphérique atypique, surtout en présence de facteurs de risque..........

[1] M.F. Amar Et Al. Tumeur Géante Du Pouce Révélant Un Adénocarcinome Pulmonaire ( A Propos D’un Cas). Chirurgie De La Main. 30(2011):133-135.
[2] M.-A. Lanfranchi Debra. Carcinome Pulmonaire Occulte A Cellules Squameuses Révélé Par Une Métastase Du Gros Orteil. Lettres A La Rédaction/Revue Du Rhumatisme 79(2012) 87-96
[3] A.Biyi Et Al. Acrométastase De La Main Et Du Pied Compliquant Un Cancer Mammaire. Chirurgie De Main 29(2010) 40-43
[4] P. Bigot Et Al. Acrométastase Révélée Par Une Douleur Isolée De La Main A Propos D’un Cas. Chirurgie De La Main 26 (2007) 300–302

Abstract: The incidence of triple-negative breast cancer (TNBC) is approximately 10-15% of all breast cancer cases around the world. It is important to search for novel therapeutic agents against TNBC since this form of cancer is a leading cause of death in women worldwide. Various genetic mutations in TNBC patients have been identified. EZH2 is an oncoprotein involved in breast, prostate, colon, and other cancers. In silico drug design and bioinformatics studies.....

Keywords : Triple Negative Breast Cancer, Drug Repurposing, Epithelial Mesenchymal Transition, Molecular Docking.

[1] Huang, Jinhua, Gou, Hongwei, Yao, Jia, Yi, Kaining, Jin, Zhigang, Matsuoka, Masao, & Zhao, Tiejun (2021). The Noncanonical Role Of EZH2 In Cancer. Cancer Science, 112(4), 1376-1382. Https://Onlinelibrary.Wiley.Com/Doi/Full/10.1111/Cas.14840
[2] “Leading Causes Of Death.” Centers For Disease Control And Prevention, 6 February 2020,
Https://Www.Cdc.Gov/Nchs/Fastats/Leading-Causes-Of-Death.Html. Accessed 30 September 2020
[3] Noer, Julie B., Hørsdal, Oskar K., Xiang, Xi, Luo, Yonglun, Regenberg, Birgitte, "Extrachromosomal Circular DNA In Cancer: History, Current Knowledge, And Methods." Trends In Genetics (2022).
Https://Www.Sciencedirect.Com/Science/Article/Pii/S0168952522000348
[4] Patel, Shivali, Charles V. Preuss, And Fidelia Bernice. "Vancomycin." Statpearls [Internet]. Statpearls Publishing, 2022. Https://Www.Ncbi.Nlm.Nih.Gov/Books/NBK459263/
[5] Samaržija I, Tomljanović M, Novak Kujundžić R, Trošelj KG. EZH2 Inhibition And Cisplatin As A Combination Anticancer Therapy: An Overview Of Preclinical Studies. Cancers (Basel). 2022 Sep 29;14(19):4761. Doi: 10.3390/Cancers14194761 . PMID: 36230683; PMCID: PMC9561994..

Abstract: Objectives: To determine the frequency of different ENT diseases presenting at outpatient department and to educate people about different ENT diseases, their early treatment and prevention.
Methodology: An observational cross-sectional study was done in Prithvichandra hospital, Nawalparasi between from May 2024 to September 2024. A non-probability convenient sampling technique was used to collect data from 250 participants from patients presenting at OPD. Data about patient particulars and different diseases was collected through a well-structured questionnaire. Data was secured and confidentiality was maintained. Data was analyzed using SPSS 21........

Keywords: ENT diseases, OPD, frequency, otitis media, medical treatment

[1]. Medicinenet. Definition Of ENT.Available From URL: Http://Www.Medicinenet.Com/Script/Main/Art.Asp?Articlekey=3252
[2]. Seth Scott Bishop Diseases Of The Ear, Nose, And Throat And Their Accessory Cavities: A Condensed Text-Book. FA Davis Company, 1897.
[3]. Khan AR, Khan SA, Arif AU, Waheed R. Analysis Of ENT Diseases At Khyber Teaching Hospital, Peshawar. J Med Sci. 2013; 21(1): 7-9.
[4]. World Health Organization. Chronic Suppurative Otitis Media. Available From URL: Http: //Www. Who.Int/Pbd /Publications/ Chronic Suppurative Otitis_Media.Pdf.
[5]. Finnbogadottir AF, Petersen H, Laxdal T, Gudbrandsson F, Gudnason T, Haraldsson A Mastoiditis In Children In Iceland Laeknabladid. 2007; 93 (4): 275-80..

Abstract: The advantage of peritoneal dialysis (PD) is its continuous nature of fluid and solute removal, with continuous sodium removal causing reduced thirst and fluid intake, thus helping with balancing fluid status 1. The steady nature of this process likely preserves residual renal functions, which in turn has a bearing on mortality2. Although PD is known to work in anuric patients, it comes at a cost of larger dose (increased volumes, no dry time), which in turn exposes the peritoneal membrane to glucose related degradation, ultimately hastening its inability to sustain PD over prolonged periods and besides exposing it to the risk of encapsulating peritoneal fibrosis. This led to the.......

[1] Hideki Kawanishi Ans Misaki Moriishi. Clinical Effect Of Combined Therapy With Peritoneal Dialysis And Hemodialysis. Perit Dial Int; Vol 27:2007; Suppl2.
[2] Churchill Dn, Thorpe Ke, Nolph Kd Et Al. Increased Peritoneal Membrane Transport Is Associated With Decresased Patient And Technique Survival For Continuous Ambulatory Peritoneal Dialysis Patients. The Canada- Usa Peritoneal Dialysis Study Group. J Am, Soc Nephrol 1998;9,1281-92.
[3] Fukui H, Hara S, Hashimoto Y, Itzami N Et Al. Review Of Combination Of Peritoneal Dialysis And Hemodialysis As A Modality Of Treatment For End Stage Renal Disease. Ther Apher Dial 2004; 8:56-61.
[4] Aggarwal M, Clinard P, Burkart Jm. Combined Peritoneal Dialysis And Hemodialysis: Our Experience Compared Tp Others. Perit Dial Int 2003; 23:157-61
[5] Mcintyre Cw. Bi-Modal Dialysis: An Integrated Approach To Renal Replacement Therapy. Perit Dial Int 2004:24:547-53..