iosr-JDMS   Volume-14 ~ Issue-7 ~ July-2015

Abstract: Giant fibroadenoma are benign tumors, but there rapid growth and large size may determine difficulties in their work up. We present a case of giant juvenile fibroadenoma of breast in girl of 16 years of age with its diagnostic workup and management. The diagnosis was made on FNAC which was confirmed by Histopathology report.

[1]. Raganoonan C, Fairbain JK, Williams S, Hughes LE. Giant breasttumours of adolesence. Aust NZ J Surg. 1987; 57:243-7.
[2]. Bauer BS, jones KM, Talbot CW. Mammary mass in the adolescent female. Surg gynecol Obstet. 1987; 165:63-5.
[3]. Nikumbh DB, Desai SR, Madan PS, Patil NJ, Wader JV. Bilateral giant fibroadenomas of breast: A case report. Patholog Res Int. 2011:482046. Epub 2011 May 30.
[4]. Rattan K, Kumar S, Dhull AK, Kaushal V, Kaur P. Giant Fibroadenoma Mimicking Phyllodes Tumor in a Young Female: A Cytological Dilemma. The Internet Journal of Third World Medicine 2008; 6:2.

Keywords: XerodermaPigmentosum(XP) is a rare autosomal recessive disorder, characterized by photosensitivity, pigmentary changes, premature skin ageing and marked increase in risk of developing malignant neoplasms of the skin and eyes. Here we present case of a sibling, 8 years old boy and 6 year old girl (Figure. 1). Girl had developed squamous cell carcinoma of left eye.

Keywords: XERODERMA PIGMENTOSUM, PHOTOSENSTIVITY, SQUAMOUS CELL CARCINOMA

[1]. Butt FM, Moshi JR, Owibingire S, Chindia ML (2010) Xerodermapigmentosum: a review and case series. J CraniomaxillofacSurg 38: 534-537.
[2]. Rao TN, Bhagyalaxmi A, Ahmed K, Mohana Rao TS, Venkatachalam K (2009) A case of melanoma in xerodermapigmentosum. Indian J Pathol Microbiol 52: 524-526.
[3]. Webb S (2008) Xerodermapigmentosum. BMJ 336: 444-446.
[4]. Lehmann AR, McGibbon D, Stefanini M (2011) Xerodermapigmentosum. Orphanet J Rare Dis 6: 70.
[5]. Genetics home reference (2010) Xerodermapigmentosum. A seminar of US national library.

Abstract: The present study aims to find significant association of serum calcium and serum uric acid levels in women with preeclampsia. METHOD: Fifty (50) preeclamptic women (cases) and forty (40) normal pregnant women (controls) were included in the study to compare serum calcium and serum uric acid levels among them. RESULTS: The serum calcium level in preeclamptic women was significantly lower with 7.74 + 0.84 mg/dL when compared to normal pregnant women with 9.35 + 0.83 mg/dL with a statistically significant 'p' value of < 0.001. The serum uric acid in preeclamptic women was significantly higher with 6.22+ 0.62 mg/dL when compared to healthy pregnant women with 4.26 + 0.85 mg/dL with a statistically significant 'p' value of <0.001.CONCLUSION:Hypocalcemia and hyperuricemia are associated with preeclampsia.

Keywords - Serum calcium, serum uric acid, preeclampsia.

[1]. ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. Obstet Gynecol 2002; 99: 159-67.
[2]. Eiland, Elosha; Nzerue,Chike; Faulkner, Marquetta (2012). "Preeclampsia 2012".Journal of pregnancy 2012: 1-7.
[3]. "Hypetension in pregnancy. Report of the American college of obstetricians and Gynacologists Task force on Hypertension in pregnancy." Obstet Gynecol.122(5): 1122-31.Nov 2013.
[4]. Golmohammad lou S, Amirabi A, Yazdian M, Pashapour N. Evaluation of serum calcium, Magnesium, Copper and Zinc levels in woman with preeclampsia. Iran J Med sci December 2008; 33(4):231-234.
[5]. Maesak JK, Fishbane S: Regulation of renal urate excretion: A Critical review. Am J Kidney Dis 32: 917-933, 1998.

Abstract:1. Detection and characterization of focal liver lesions.
2. Differentiation of benign from malignant liver lesions.
3. Differentiation of liver metastasis from primary liver lesions.
4. To compare respiratory triggered diffusion weighted single shot echo planar imaging (RT DW-SS-EPI) and T2 weighted turbo spin echo imaging (T2W TSE).
5. To determine apparent diffusion coefficients (ADCs) of focal liver lesions and normal liver parenchyma.

[1]. Demir Öİ, Obuz F, Sağol Ö , Dicle O. Contribution of diffusion-weighted MRI to the differential diagnosis of hepatic masses. DiagnInterv Radiol.2007; 13:81-86.
[2]. Kele P,Van der Jagt, E.World J Gastroenterol. 2010 April 7; 16(13): 1567–1576.
[3]. Stejskal EO, Tanner JE. Spin diffusion measurements: spin echoes in the presence of a time-dependent field gradient. J ChemPhys 1965;42:288–292.
[4]. Le Bihan D et al. MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. Radiology 1986;161:401–407.
[5]. Taouli B, Koh DM. Diffusion-weighted MR imaging of the liver. Radiology 2010 Jan;254(1):47-66.
[6]. Kilickesmez O, Bayramoglu S, Inci E, Cimilli T. Value of apparent diffusion coefficient measurement for discrimination of focal benign and malignant hepatic masses. J Med Imaging RadiatOncol. 2009 Feb;53(1):50-5.
[7]. Miller, F.H., Hammond, N., Siddiqi, A.J., Shroff, S., Khatri, G., Wang, Y., Merrick, L.B. and Nikolaidis, P. Utility of diffusion-weighted MRI in distinguishing benign and malignant hepatic lesions. Journal of Magnetic Resonance Imaging, 2010;32: 138–147.