Series-3 (May-June 2019)May-June 2019 Issue Statistics
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| Paper Type | : | Research Paper |
| Title | : | N-Nitroso-2, 6- Diphenylpiperidin-4-One Semicarbazone Synthesis, Characterization, Antioxidant Activity and Molecular Docking with its Binding Site |
| Country | : | India |
| Authors | : | Debaprotim Dasgupta || Jun Moni Kalita || Mr Kamallochan Barman |
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: | 10.9790/3008-1403030106  |
Abstract: Piperidines are very important compounds because of their presence in numerous alkaloids, pharmaceuticals, agrochemical and as synthetic intermediates. Biologically active alkaloids of the substituted piperidine ring system have been targeted for their total or partial synthesis. Synthetic efforts were also made fro modifications of pethidine and morphine like compounds, which led to the synthesis of new opiate having agonist as well as antagonistic......
Key words: N-nitroso-2,6- diphenylpiperidin-4-one semicarbazone, antioxidant activity , docking
[1]. Taniguchi T, Ogasawara KA (2000) Diastereo controlled synthesis of (+)-febrifugine: a potent antimalarial piperidine alkaloid. Org Lett 2: 3193-3195.
[2]. El-Subbagh HI, Abu-Zaid SM, Mahran MA, Badria FA, Al-obaid AM, et al. (2000) Synthesis and biological evaluation of certain alpha, beta-unsaturated ketones and their corresponding fused pyridines as antiviral and cytotoxic agents. J Med Chem 43: 2915-2921.
[3]. Jerom BR, Spencer KH (1988) Preparation and testing of 4-heterocyclylacylamino piperidine sasnarcotic antagonists and analgesics. Eur Pat Appl EP 277794.
[4]. Frietas RM, Silva FO, Silva MG, Feng D. Antioxidant mechanisms of iso-cassine in suppressing seizures induced by pilocarpine. Braz J Pharmacog 2011; 21:437-43.
[5]. Alexidis AN, Rekka EA, Demopoulos VJ, Kourounakis PN. Novel 1,4 substituted piperidine derivatives. Synthesis and correlation of antioxidant activity with structure and lipophilicity. J Pharm Pharmacol 1995;47:131-7...
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| Paper Type | : | Research Paper |
| Title | : | Studies on the Antibacterial Potency of Annona Senegalensis Pers. (Annonaceae) Extract on Bacteria Associated with Wound Infection |
| Country | : | Nigeria |
| Authors | : | Dawang,DN || Ayanlere, JR || Dawang,SN |
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: | 10.9790/3008-1403030711 |
Abstract: Natural products, particularly those from plants, have been used as vital tool to help mankind in sustaining health care delivery systems. Thus, this research aimed to determine the efficacy of Annonasenegalensis against some bacteria associated with wound infection. Leaf preparation of A. senegalensis is used as ethnomedicine for the treatment of wound and organisms associated with wound.Leaf extract of A. senegalensis was obtained by macerating the powdered leaf of 57.89g into 440ml of methanol which yielded 8.5g(14.68%).The phytochemical constituents of the methanol leaf extract of A. senegalensis were determined using standard qualitative procedure. The antibacterial activity was performed using agar well diffusion method.The phytochemical........
Keywords: Annonasenegalensis, Studies,Antibacterial Activity,Wound Causing Bacteria, Phytochemistry
[1]. Adeshina, G.O. Tashir, T.S andOnaolapo, J.A. (2010); Microbiological Evaluation of Packaged Pineapple Juice market in Kaduna metropolis.‗Nigeria Journal of Pharmaceutical Research vol. 8. No. 1 pp 281-287
[2]. Adigun,M.O.,Afolabi,O.O.,Agbaje-Daniels,F.V.,Okonofua,C.C and Lateef,S. A.(2018). Antibiotic Susceptibility Profile of Microbial Isolates from Open Wounds to Common Antibiotics.Nigerian Journal of Microbiology. 32(1 &2):4148-4157.
[3]. Ajaiyeoba, E. Falade, M. Izabe, K. Akumka, D andGamaniel, K. (2005).Effect of AnnonasenegalensisRootbark Extracts on Najanigricolisnigricolis Venom in Rats. Journal Ethnopharmacol. 96:507-513
[4]. Ajaiyeoba, E.O (2002). Phytochemical and antibacterial properties of Parkiabiglobosa and extracts.African Journal of Biomedical Research 5, 125–129.
[5]. Apak, L. and Olila, D. (2006).‗The in vitro Antibacterial Activity of Annona senegalensis.Securudacccalongipediculate and Steganotteaniaaraliacea-Uganda medicinal plant'.Africa Health Science vol. 68. No. 1-3 pp289-294
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| Paper Type | : | Research Paper |
| Title | : | Effects of Exposures to Low-Dose X-Rays on Blood Cell Morphologies of Radiographers in Port Harcourt |
| Country | : | Nigeria |
| Authors | : | Wejie-Okachi, Chinunam || Agi, Chukuemeka || Douglas, Kingsley |
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: | 10.9790/3008-1403031221 |
Abstract: X-rays are electromagnetic waves that can traverse the human body due to their high energy levels (≥1.24 keV) and ultra-short wavelengths (≤10-10m). Acute exposures have harmful health effects, affecting hematopoietic systems amongst others. X-ray unit workers experience these effects despite usage of Personal Protective Equipment (PPEs). This study spanned May 2018 to February 2019, and was aimed at determining the effects of exposures to low-dose x-rays on basic morphological characteristics of blood cells among radiographers in Port Harcourt. It was delimited to a target population of active radiographers who work for ≥ 6-hours daily; ≥ 5-days weekly...........
Key words: Ionizing radiation, background radiation, blood cell morphology, poikilicytosis, anisocytosis, microcytosis, atypical lymphocytes, codocytes
[1]. Abubakar, A., Sadiq, A., Musa, M., Hassan, J., Malgwi, D. (2016). Assessment of Indoor Ionizing Radiation Profile in radiology department, FMC Asaba, Delta State, Nigeria.IOSR Journal of Dental and Medical Sciences (IOSR-JDMS).e-ISSN: 2279-0853, p-ISSN: 2279-0861. 16(1), ver. VI: pp 98-101. Available at http://www.iosrjournals.org/iosr-jdms/papers/Vol16-issue1/Version-6/R16010698101.pdf. Accessed in August, 2017.
[2]. Alnahhal, M., Alajeramy, Y., Abu-Mostafa, S.,Abu-Shab, K., Jaber, S., Najim, A. (2017). Assessment of hematological parameters among medical radiographers at governmental hospitals, Gaza Strip, Palestine.American J. of Medicine and Medical Sci. 7(6): 238-241. Doi: 10.5923/j.ajmms.20170706.02. Available at https//10.5923.j.ajmms20170706.02.pdf. Accessed October, 2017
[3]. Boon, N., Colledge N., Walker, B., and Hunter, J. (2006). Oncology.Davidson‟s Principles and Practice of Medicine.20th ed. Churchill Livingstone (Elsevier), London-Eng. Ch.11; pp254-265. ISBN 978-0-443-10133-5
[4]. Brenner, D. and Hall, E. (2007). Computed Tomography: An increasing source of radiation exposure.Current concepts.The New England J. of medicine. 357(22):2277-2284.
[5]. Briggs-Kamara, M., Okoye, P., and Omubo-Pepple, V. (2013). Radiation safety awareness among patients and radiographers in three hospitals in Port-Harcourt.American journal of scientific and industrial research.4(1): pp83-88. Avail. https://doi.org/10.5251/ajsir.2013.4.1.83.88. Accessed August, 2017.
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| Paper Type | : | Research Paper |
| Title | : | Effect of Ethanol Extract of Gnetum africanum leaves on the Lipid Profile of Albino Rats |
| Country | : | Nigeria |
| Authors | : | Eneh, F.U. || Ugochukwu, G.C. || Okeke, C.R |
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: | 10.9790/3008-1403032225 |
Abstract: The implication of hypercholesterolemia in metabolic maladies has informed research on a wide spectrum of diet-based interventions in lowering serum cholesterol levels. This work investigated the effect of ethanol extract Gnetum africanum leaves on the lipid profile of Wister rats. A total of 12 rats divided into two groups of 6 rats each were employed in the investigation. The first group (control) were fed rat chow while the second group (test) were fed a composite feed containing rat chow and 10% extract of G. africanum leaves. The lipid profile (total cholesterol, triglycerides, LDL, HDL) of the rats was assayed after 18 days of feeding.The result showed..........
Key words: Gnetum africanum, leaves, lipid profile, hyperlipidemia, wistar rats & ethanol extract.
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[2]. Coelho, M., Oliveira, T. &Fernandes, R. Biochemistry of adipose tissue: an endocrine organ. Arch. Med. Sci. AMS9, 191–200 (2013).
[3]. Strong, A. & Rader, D. J. Clinical Implications of Lipid Genetics for Cardiovascular Disease. Curr. Cardiovasc. Risk Rep.4, 461–468 (2010).
[4]. Kris-Etherton, P. M. et al. The effect of diet on plasma lipids, lipoproteins, and coronary heart disease. J. Am. Diet. Assoc.88, 1373–1400 (1988).
[5]. Szostak-Wegierek, D., Kłosiewicz-Latoszek, L., Szostak, W. B. &Cybulska, B. The role of dietary fats for preventing cardiovascular disease. A review. Rocz. Panstw. Zakl. Hig.64, 263–269 (2013)..
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| Paper Type | : | Research Paper |
| Title | : | The Maternal Pregnancy Outcomes Following Prenatal Administration of Varied Doses of Carbamazepine inAlbino rats (Rattus norvegicus) |
| Country | : | Kenya |
| Authors | : | Mwangi A. Wairimu || Kweri J. Kariuki || Malik A. Nyabola || Thuo Reuben || Kafaya G. Kibe |
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: | 10.9790/3008-1403032634 |
Abstract: TheIn-utero exposure to carbamazepine has been shown to perturb maternal digestion as well as cell and tissue metabolic processes when used during pregnancy. Literature has shown thatit perturb the endogenous bioelectrical mechanisms and voltage gradients that guides maternal metabolic pathways of cells and tissues. Further, it also disturbs the fetal growth and development as it interferes with fetal patterning programs,cell division, cell positioning, and cell differentiation as it readily crosses the maternal placental barrier. Though, literature........
[1]. Afshar M, Moallem SA, Mohammadpour AH. Teratogenic effects of carbamazepine on embryonic eye development in pregnant mice. 2009;(November). doi:10.3109/15569520903380353.
[2]. El-gaafarawi I, Abouel-magd M. Teratogenic Effect of Carbamazepine Administration in Pregnant Rats. 2015;59:244-257. doi:10.12816/0012182.
[3]. Jentink J, Dolk H, Loane MA, Morris JK, Wellesley D, Garne E. Intrauterine exposure to carbamazepine and specific congenital malformations : systematic review and case-. :1-7. doi:10.1136/bmj.c6581.
[4]. Elshama SS, Eldin H, Osman H, El-kenawy AE. Teratogenic effect of Carbamazepine use during pregnancy in the mice. 2006:6-8.
[5]. Baerwald AR, Adams GP, Pierson RA. Form and function of the corpus luteum during the human menstrual cycle. 2010;25(5):498-507. doi:10.1002/uog.1891.Form.
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| Paper Type | : | Research Paper |
| Title | : | A Comparative Study on Antimicrobial Activity in Different Varieties of Bangladeshi Citrus Species |
| Country | : | Bangladesh |
| Authors | : | Md. Maniruzzaman || Ashik Mosaddik || Nurunnahar || Md. Abu Zubair || Md. Moksadul Amin || Md. Shahidul Haque || Md. Hazrat Ali |
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: | 10.9790/3008-1403033545 |
Abstract: Fruit peels are major byproduct of processing food and are not currently used commercially, but it can be a potential antimicrobial agent. As microorganism resistance to marketed antibiotics is prime concern now a day, the study concentrated on potential antibacterial activity of the following citrus species grown in Bangladesh. The purpose of the present study is to evaluate the peel of ten Bangladeshi citrus species namely C. maxima (local name, Batabilebu), C. reticulate (local name, Khasikomla), C. medica (local name, Jaralebu), C. sinensis (local name, Malta), C. lemon (local name, Lebu), C. hystrix (local name, Satkora), C. assamensis (local name, Adalebu), C. limittoids...........
Key words: Citrus peel, Antibacterial effects, Methanol extract, Antioxidants, Phytonutrients
[1].
Alesiani, D., A. Canini, B. D'Abrosca, M. DellaGreca, A. Fiorentino, C. Mastellone, P. Monaco, and S. Pacifico, Antioxidant and antiproliferative activities of phytochemicals from Quince (Cydonia vulgaris) peels. Food Chem., 2010, 118: 199-207.
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Sadek, E.S., D.P. Makris, and P. Kefalas, Polyphenolic composition and antioxidant characteristics of Kumquat (Fortunella margarita) peel fractions. Plant Foods for Human Nutrition, 2009, 64(4): 297-302.
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Ajila, C.M., M. Aalami, K. Leelavathi, and U.J.S.P. Rao, Mango peel powder: a potential source of antioxidant and dietary fibre in macaroni preparations. Innovative Food Science and Emerging Technologies, 2010, 11: 219-224.
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Ayala-Zavala, J.F., S.Y. Wang, C.Y. Wang, and G.A. Gonzalez-Aguilar, Effect of storage temperatures on antioxidant capacity and aroma compounds in strawberry fruit. Lebensm.-Wiss. u.-Technol., 2004, 37: 687-695.
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Olaniyan, A.M., Development of a small scale orange juice extractor. J. Food Sci. Technol., 2010, 47(1): 105-108
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| Paper Type | : | Research Paper |
| Title | : | Effects of Smoking on Amino Acid Content in Domesticated and Wild Tilapia |
| Country | : | Nigeria |
| Authors | : | Oko, Augustine Okpani || Eluu Stanley || Agwu Samuel C || Ehihia Loveth || Ngele Kalukalu || Okoye, Emeka Desmond || Oluwole, Akinjide Omoniyi || Okorie, Joseph Michael |
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: | 10.9790/3008-1403034651 |
Abstract: Amino acids are the building blocks of protein and there are about 300 known amino acids if not more, that has been described and categorized, but only about 20 amino acids are consistently involved in biological build up.Traditional technique of preserving fish (by smoking) was investigated to understand its effect on the nutritional quality of tilapia and present human dietary needs. This study is aimed at evaluating the amino acid content of tilapia before and after drying (smoking).For this study tilapias were obtained from three major sources, two domesticated sources (ponds) and a wild source (river). The method used was that described by Benitez.Results from this study..........
Key words: Amino acids, smoking, tilapia, domesticated and wild
[1]. Cahu, C., Salen, P., and De Lorgeril, M. (2004). Farmed and wild fish in the prevention of cardiovascular diseases, Assessing possible differences in lipid nutritional values. Nutrition Metabolism and Cardiovascular Disease, 14: 34-41.
[2]. Drotningsvik, A., Mjos, S. A., Hogoy, I., Remman, T., and Gudbrandsen, O. A., (2015). A low dietary intake of cod protein is sufficient to increase growth, improve serum and tissue fatty acid compositions, and lower serum postprandial glucose and fasting non-esterified fatty acid concentrations in obese Zucker fa/fa rats. European Journal of Nutrition, 54: 1151–1160.
[3]. El, S.N. and Kavas, S.N. (1996). Determination of protein quality of rainbow trout (Salmo irideus) by in vitro protein digestibility-corrected amino acid score (PDCASS). Food Chemistry, 55(3): 221-223.
[4]. Elagba, M. H. A., Al-Maqbaly, R., and Mansour, H. M. (2010). Proximate composition, amino acid and mineral contents of five commercial Nile fishes in Sudan. African Journal of Food Sciences,4(10): 650-654.
[5]. Erkan, N., Özden, Ö. and Selçuk, A. (2010). Effect of frying, grilling, and steaming on amino acid composition of marine fishes. Journal of Medical Food.13(6): 1524–1531.
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| Paper Type | : | Research Paper |
| Title | : | Extent of Hallucinogen Drug Abuse among Secondary School Students in Ebonyi State |
| Country | : | Nigeria |
| Authors | : | Aleke Christian Okechukwu || Omaka-Omari Lois Nnenna || Obande-Ogbuinya Nkiru Edith || Ngwakwe Patricia C || Uraku Anayo Joseph |
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: | 10.9790/3008-1403035263 |
Abstract: Background and objective: The use of drugs does not constitute an evil. Drug can be used both positively and negatively and if not properly used, drugs can have serious consequences. This descriptive survey was conducted to determine the extent of Hallucinogen drug abuse among secondary school students in Ebonyi State, Nigeria. Materials and Method: this was a cross-sectional study that used web based questioners given in 2013. Total of 674 students were used for the study and 672 representing about 98.8% were used for data analysis. Results: The results of the study showed that secondary school students do not abuse hallucinogen drugs as their cluster mean is 1.27; that the extent of hallucinogen drug abuse was dependent on gender and age as P-value =.296..........
Key words: Drug Abuse, Hallucinogen, Students, Ebonyi State.
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| Paper Type | : | Research Paper |
| Title | : | A study to assess the effectiveness of citric acid in healing foot ulcer among diabetic patients at Sree Balaji Medical College and Hospital, Chennai |
| Country | : | india |
| Authors | : | Rojarani.K |
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: | 10.9790/3008-1403036471 |
Abstract: Background of the study: Diabetes mellitus is a metabolic disorder which is characterized by multiple long-term complications that affect almost every system in the body. Foot ulcers are one of the main complications of diabetes mellitus. Various recommendations and practices are experimented to reduce the diabetes foot ulcer.
Aims: to assess the effectiveness of citric acid in healing foot ulcer among diabetic patients with the selected demographic and clinical variables among the patients with diabetic foot ulcer.
Methodology The study was conducted in surgical wards at Sree Balaji Medical College Hospital, Chennai Diabetic patients who are admitted with foot ulcer during the period of data collection. The investigator followed a Qualitative research design was used for this study is pre test and post test design. Convenient sampling of 40 patients, age group between 35 to70........
Key words: Diabetes foot ulcer, citric acid dressing, healing, Lydia hall, bates Jansen scale
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