iosr-JPBS   Volume-13 ~ Issue-2 ~ March-April 2018

Abstract: The main objective of the present work was to formulate and evaluate sustained release lamivudine tablets using different polymers viz. Microcrystalline cellulose (MCC),Poly vinylpyrrolidine K30 (PVP K30) and gums like Chitosan,Guar gum,Xanthum gum .Then the release rates were modulated. After evaluation of physical properties of tablet, the in-vitro drug release study was performed in 0.1N HCl for 2 hours and in phosphate buffer pH 6.8 upto 12 hours. Dissolution data were analysed by Higuchi plot.Among all the formulations, formulation F9 which contains chitosan release the drug which follows First order kinetics was showing highest drug release retarding capacity.

Abstract: The Combination Of Metformin Hcl And Ezetimibe Is Used For The Management Of Type Ii Diabetes Mellitus. The Present Research Work Was Carried Out To Develop A Bilayer Tablet Of Metformin Hcl As Extended Release Layer Which Was Prepared By Using Hydrophilic Matrix Polymers Such As Eudragit Rs100, Peo And Carbapol And Ezetimibe As Immediate Release Layer.Drug Release From The Matrix Was Found To Decrease With Increase In Polymer Concentration.Er6 Gave Better Release When Compared To All Formulations. The Angle Of Repose, Bulk Density, Tapped Density And Compressibility Index Results Has Shown That The Formulation Is Suitable For Wet Granulation Method.The Drug Release Kinetics Of The Optimized Bi-Layered Tablets Corresponded Best To Korsmeyer- Peppas Model And The Drug Release Mechanism As Per ' N' Value Of Korsmeyer - Peppas Is Anomalous (Nonfickian) Diffusion And The Tablets Showed No Significant Change In Physical Appearance, Drug Content Or In Vitro Dissolution Pattern.

Abstract: The present study was undertaken to explore the antibacterial, cytotoxic and analgesic activities of the ethanolic extract (ET) of Feronia limonia fruit pulp. The pulp of elephant apple was extracted with ethanol by cold extraction procedure. We found that the ET contains active phytochemicals that showed potential antimicrobial, cytotoxic and analgesic activities. Briefly, ET showed better activities on average against both and the highest activity was found against Sarcina lutea (in case of gram positive) and Shigella shiga (in case of gram negative) with significant MIC values. Additionally the ET extract of Feronia limonia fruit pulp possesses cytotoxic activity and LC50 was found to be in the dose of 48.76143μg/ml...............

Keywords: Analgesic, Antimicrobial, Cytotoxicity, Ethanol Extract And Katbel (Feronia Limonia).

Abstract: Findings Display That The Butterflies Play Asignificant Role In Cross-Pollination Of Marigolds At Gandhi Nagartehsil -Ambikapur,Surguja.Of79 Individuals, 15 Species Of Butterflies Have Been Identified. Family NnymphalidaeHas Maximum Number Of Species (8 Species), Followed Bylycaenidae (2 Species),Pieridae(2 Species), Hesperidae(2 Specie) And Papilionidae(1 Species). These Butterflies Are More Active Between 10.00-13.00 Hours Of The Bright Sunny Day With Compare To Cloudy And Rainy Days. ColourAnd Fragrance Of Flowers Have An Influential Potentiality To Attract More Number Of Floral Visitors...........

Keywords: Ambikapur, Nymphalidae, Lycaenidae, Pieridae, Hesperidae, Papilionidae, AsteraceaeAnd Butterflies.

Abstract: Hemodialysis is a process of purifying the blood of a person whose kidneys are impaired. The objective of the study is to assess the efficacy/adequacy of Hemodialysis by calculating the Kt/V ratio (ideal value= 1.4) and URR ratio (65%) (KDOQI) and to evaluate the quality of life of the patient based on the KDQOL sf 36 questionnaires. This is an observational study conducted for a period of seven months in a quaternary care hospital. 496 Hemodialysis data were collected. The adequacy of Hemodialysis dose was calculated using Kt/V and URR standards. The quality of life was evaluated by KDQOL SF 36 questionnaires and the relationship between the Hemodialysis adequacy and the quality...........

Keywords: Adequacy,Hemodialysis dose, Glomerular Filtration Rate, Quality of Life.

Abstract: Introduction: Buruli ulcer (BU), caused by Mycobacterium ulcerans, is a severe necrotizing disease affecting the skin, subcutaneous adipose tissue and occasionally bones. This neglected tropical infection was regarded as an emerging infectious disease by World Health Organization (WHO) in 1998. BU as the third most common mycobacterial disease, after tuberculosis and leprosy, has been reported in more than 30 countries worldwide. The disease is characterized with the production of mycolactone. The mode of transmission is poorly understood but the controversial role of aquatic insects and mosquitoes has been proposed. This study as a part of an ongoing research project aimed at determining the genomic epidemiology of Buruli ulcer disease (BUD) in Southwest, Nigeria, gives an index occurrences in four of the six states in the region............

Keywords: Buruli ulcer, Mycobacterium ulcerans, case search, southwest Nigeria.

Abstract: Aim:To study the medication adherence among type 2 DM patients at a tertiary care hospital. Materials and methods: A cross sectional observational study was conducted for a period of 6 months in a general medicine department. A total of 100 type 2 DM patients ,who were on antidiabetic drug therapy for atleast 1 year were enrolled. Blood gluose levels were measured periodically and details of drug therapy were recorded.Medication adherence were assessed by using Morisky Medication Adherence scale and counseling were provided inorder to improve the medication adherence. Results :The study results was analyzed by using KAP(Knowledge,Attitude,and Practices) and Morisky Medication Adherence scale which shows the P value...........

Abstract: It is high time to search for novel antimicrobial agents as the bacterial drug resistance is increasing day by day. Spices have been believed to contain medicinal values from ancient time and posses less side effects in comparison to commercial drugs. Our study compares the antibacterial activity of ethanol extracts of Garlic (Allium sativum), Clove (Syzygium aromaticum), and Cinnamon (Cinnamomum zeylanicum) against Escherichia coli, Vibrio cholera, Staphylococcus aureus, Bacillus cereus, Salmonella sp, Shigella sp, Serratia sp, Acinetobacter sp, and Klebsiella sp. The primary antibacterial activity and minimum inhibitory concentration (MIC) were determined by agar well diffusion and broth dilution methods...........

Keywords: Antibacterial activity, Ethanol Extract, MIC, MBC and Synergistic effect.

Abstract: Organic fertilizers contain relatively low concentrations of the actual plant nutrients and are not immediately available for plant utilization. Hence, the fortification of organic wastes and their composts as a source of organic nutrients are imperative for sustainable agriculture. This paper was representedthe 18physico-chemical parameters from different compost. Among tested organic fertilizers,Fard Yard Manure (FYM)(56%) showed highest ash content followed by vermicompost (53.15%). pH contents found almost alkaline in nature except cow dung manure.EC was found highest in poultry manure (0.83) while less in baggase ash(0.17).Nitrogen content is found highest in baggase ash than other compost............

Keywords: Organic Composts, physicochemical parameters, Growth and Yieldof crop plant.

Abstract: Present paper deals with, detailed assessment of mycorrhization establidhed by Arbuscular Mycorrhizal Fungi with Eriocaulon eurypeplon Körn. It is endemic pipewort to the Western Ghats of India. Here, sixteen species of AM fungi viz., Acaulospora denticulate, Aculospora radilatata Morton., Acaulospora elegans, Acaulospora rehmii, Acaulospora spp., Acaulospora thomii; Ambispora granatensis, Diversispora epigaea, Gigaspora margarita, Gigaspora rosea, Glomus dimorphicum, Glomus fasciculatum, Glomus maculosum, Glomus pallidum, Scutellospora dipurpusescrns and Septoglomus constrictum were identified in association with Eriocaulon eurypeplon. Based on spore density and relative abundance only Acaulospora rehmii was found as dominant AM fungal species. In this paper Eriocaulon eurypeplon is proposed as mycorrhizal endemic pipewort.

Keywords: Arbuscular mycorrhizal fungi, AM fungi, endemic plant, Eriocaulon eurypeplon Körn.