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| Paper Type | : | Research Paper |
| Title | : | Pharmacological Uses and Isolated Chemical Constituents of Ipomoea Digitata: A Review |
| Country | : | India |
| Authors | : | Garima Ojha || K.N.Mishra || Arun Mishra |
Abstract: The plant Ipomoea digitata belongs to Convolvulaceae family. Ipomoea is the largest species of this family. This plant is found throughout the tropical and subtropical region. In India the plant is taken as raw food. From the ancient period of time this plant was used as hypoglycemic, anti-inflammatory, anticonvulsant, and aphrodisiac agent. The present work was about the review of different pharmacological properties and isolated chemical constituents of the plant Ipomoea digitata
Keywords: Ipomoea digitata, Antidiabetic, Antihypertensive, Antioxidant, Galactogogue, sperm density.
[1]. Meira Marilena, Pereira da Silva Eliezer, David Jorge M., David Juceni P. Review of the genus Ipomoea: traditional uses, chemistry and biological activities, Brazilian Journal of Pharmacognosy, 2012; 22(3): 682-713.
[2]. Khare C.P., Indian Medicinal Plants, Springer, 2007:331.
[3]. Jain Vartika, Verma SK, Katewa SS, Therapeutic validation of Ipomoea digitata tuber (Ksheervidari) for its effect on cardio-vascular risk parameters, Indian Journal of Traditional Knowledge; 2011, 10(4) : 617-23.
[4]. Singh MP & Panda H, Medicinal herbs and their formulations, Vol II, (Daya publishing house, New Delhi), 2005:, 498-499.
[5]. Joy P. P., Thomas J., Mathew Samuel, Skaria Baby P., Medicinal Plants, Kerala Agricultural University, Aromatic and Medicinal Plants Research Station, 1988:193.
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| Paper Type | : | Research Paper |
| Title | : | Drugs Induced Nausea and Vomiting: an Overview |
| Country | : | Malaysia |
| Authors | : | Thinn Yu Aung || Shelly Soo |
Abstract: Every drug can produce untoward consequences and side effects, even when used according to standard or recommended methods for administration. Adverse drug reactions can involve every organ and system of the body and are frequently mistaken for signs of underlying disease. Similarly, gastrointestinal tract can be affected by many drugs or chemicals.
[1] Yamada T, Alpers DH, Owyang C, et al. Handbook of Gastroenterology. Philadelphia, Pa: Lippincott-Raven Publishers; 3rd edition, 2013 Ghahremani GG. Gastrointestinal complications of drug therapy. Abdom Imaging. 1999; 24:1-2.
[2] Clark-Vetri RJ. Management of chemotherapy-induced emesis. Pharm Times. 1999; 65:78-85.
[3] American Cancer Society and National Comprehensive Cancer Network. Nausea and Vomiting: Treatment Guidelines for Patients with Cancer (Version IV 2007). www.nccn.org/patients/patient_gls.asp.
[4] Garrett K, Tsuruta K, Walker S, Jackson S, Sweat M. Managing nausea and vomiting. Current strategies. Crit Care Nurse. 2003;23(1):31-50.
[5] Jordan K, Sippel C, Schmoll HJ. Guidelines for antiemetic treatment of chemotherapy-induced nausea and vomiting: past, present, and future recommendations. Oncologist. 2007;12:1143-1150.
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| Paper Type | : | Research Paper |
| Title | : | Development and in Vitro Evaluation of Ambroxol Hydrochloride Niosomes Using Thin Film Hydration Method |
| Country | : | India |
| Authors | : | Parika Singh || Mrs.Nitya Shanti || Basant Sharma || Neha krishnarth |
Abstract: Niosomes (non-ionic surfactant vesicles) are microscopic lamellar structures obtained on admixture of non-ionic surfactant of the alkyl or dialkyl polyglycerol ether class and cholesterol with subsequent hydration in aqueous media. The main objective of research work provides sustained release of drug, maximum therapeutic effect for a long period of time, also decreases the frequency of dosing. Ambroxol HCl used as model drug, used in pulmonary bronchitis. Therefore formulation of Ambroxol HCl as niosomes would provide advantages of sustained release dosage forms.......
Keywords: Ambroxol Hydrochloride (AMB), Cholesterol, DCP, Niosomes, Span 20, Span60, Tween60, Tween80, Thin film hydration method.
[1] Gieringer D H, The safety and efficacy of new drug approval. Cato Journal.1985; 5:177–201.
[2] Hao Y, Zhao F, Li N, Yang Y, Li K. Studies on a high encapsulation of colchicine By a niosome system. International Journal of Pharmaceutics 244 (2002) 73–80.
[3] Fang J Y, Yu S Y, Wu P C, Huang Y B, Tsai Y H. In vitro skin permeation of estradiol from various proniosomes formulations. Int J Pharm. 2001; 215:91–99.
[4] Manconi M, Sinico C, Valenti D, Loy G, Fadda A M. Niosomes as carriers for tretinoin. I. Preparation and properties. Int J Pharm.2002; 234:237–248.
[5] Manconi M, Valenti D, Sinico C, Lai F, Loy G, Fadda A M. Niosomes as carriers for tretinoin II. Influence of vesicular incorporation on tretinoin photostability. Int J Pharm. 2003; 260:261–272.
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| Paper Type | : | Research Paper |
| Title | : | Effect on the Probionts to the Enhancement of Silk Proteins (Sericin and Fibroin) in the Silk Gland and Cocoons of Silkworm (L× CSR2) Bombyx Mori (L.) |
| Country | : | India |
| Authors | : | Sekar, P. || Kalpana, S. || Ganga, S. || George John || Kannadasan, N. |
Abstract: The domesticated silkworm, Bombyx mori (L), a Lepidopteran molecular model and an important economic insect. The silkworm, B. mori produces massive amount of silk proteins during the final stage of larval development (Fifth instars). These proteins are stored in the middle silk gland and they are discharged through the anterior duct and spinneret, at the end of the fifth instar. There two kinds of silk proteins have been distinguished as major components of silk cocoons, the first being real silk fibre namely fibroin (H-chain), and the second being adhesive substance namely sericin (L-chain)........
Keywords: Probionts, Silk Gland, Cocoon, Silk Proteins, SDS-PAGE.
[1]. Y. Zhang, P. Zhao, Z. Dong, D. Wang, P. Guo, X. Guo, Q. Song, W. Zhang and Q. Xia, Comparative proteome analysis of multi-layer cocoon of the silkworm, Bombyx mori, PLoS ONE, 10(4), 2015, 1-14.
[2]. M. Mondal, K. Trivedy, and S. Nirmal Kumar, The silk proteins, sericin and fibroin in silkworm, Bombyx mori Linn.,-a review, Caspian Journal of Environmental Sciences, 5(2), 2007, 63-76.
[3]. S. Sivaprasad and P. Murali Mohan, Amino acids, aminotransferases and proteins in the metamorphosing silkworm, Bombyx mori L. Proc. Indian Acad. Sci., (Anim. Sci.), 99, 1990, 369-375.
[4]. M. Nagata and J. Kobayashi, Effect of nutrition on storage protein concentrations in the larval haemolymph of the silkworm, Bombyx mori., Journal of Sericultural Science, 59, 1990, 469-474.
[5]. A. Choudhuri, and A.K. Medda, Thyroxin-induced alterations in glycogen content of fat body of female silkworm Bombyx mori (race Nistari) during larval, pupal and adult stages of development. Annals of Entomol., 1992, 10-21.
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| Paper Type | : | Research Paper |
| Title | : | Role OfBioregulator On Proline, Proteins And Soluble Sugar Ac-cumulation In Organs Of Okra Under Salinity Stress |
| Country | : | Nigeria |
| Authors | : | Esan A.M || Olaiya C.O |
Abstract: Okra is an important vegetable grown in tropical and sub-tropical regions. Here, we study its re-sponse to salinity stress. Seeds of 47-4 and LD88 genotypes were pre-soaked with indole acetic acid (0.4, 0.5 and 0.6mM) and control in distilled water. The seeds were grown in polyethylene bags under different levels of salinity (50, 100, 150 and 200 mMNaCl).Experiment was conducted to study the interactive effect of salinity and bioregulator on growth and accumulation of solutes (proline, salt stress proteins and soluble sugar). Salinity stress in all levels increased proline content in the two genotypes in increasing order in the absence of indole acetic acid......
Keywords: Distilled water, Indole acetic acid, Okra, Proline, Protein, Salinity, Sugar
[1]. Ackerson, R. C. 1985. Osmoregulation of cotton in response to water stress III. Effects of phosphorus fertility. Journal of Plant Physiology. 77: 309-312.
[2]. Ahmad M, Arif MI, Ahmad Z .2003. Susceptibility of Helicoverpaarmigera(Lepidoptera:Noctuidae) to new chemistries in Pakis-tan. Crop Prot. 22: 539-544.
[3]. Ahmad P .2010. Growth and antioxidant responses in mustard ( BrassicajunceaL.) plants subjected to combined effect of gibberel-lic acid and salinity. Arch Agron Soil Sci 56:575–588.
[4]. Ahmad P, Nabi G, Ashraf M .2011. Cadmium-induced oxidative damage in mustard [ Brassicajuncea(L.) Czern. &Coss.] plants can be alleviated by salicylic acid. South Afr J Bot 77:36–44.
[5]. Amin B, Mahleghah G, Mahmood HMR, Hossein M .2009. Evaluation of interaction ef fect of drought stress with ascor-bate and salicylic acid on some of physiological and biochemical parameters in okra (Hibiscus esculentusL.). Res. J. Biol. Sci.4: 380-387.
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| Paper Type | : | Research Paper |
| Title | : | In Vitro Anticoccidial Activity of Methanolic Leaves Extract of LanneaShimperiAgainst Oocystsof EimeriaTenella |
| Country | : | Nigeria |
| Authors | : | H.G. Mikail || M.Yusuf || G. Hussain |
Abstract: Eimeriabelonging to the phylum apicomplexan protozoa is recognized as the the major parasitic disease of poultry. Caecalcoccidioisis caused by Eimeriatenella is a major threat to poultry production. The drugs which can inhibit sporulation process are best choice as preventive measures. Anticoccidial drugs have played a major role in the effective control of avian coccidiosis, but, their extensive use has resulted in the emergence of drug resistant coccidian strains which necessitates sourcing of better alternative drugs. The present study is aimed at evaluating the in vitro anticoccidial potential of the methanolic leaves extract of Lanneaschimperi.......
Keywords: Anticoccidial activity, Eimeriatenellaoocysts, Lanneaschimperi, methanolic leaves extract.
[1]. A.F.M.F. Islam, S.W. Walkden-Brown and B. Wells, Litter pasteurization: effects of cover and moisture level on the temperature of the litter heap,Proc. Aust. Poult. Sci. Symp., 2013, 21: 179-182.
[2]. M.C. Jenkins, C. Parker, C. O'Brien, K. Miska and R. Fetterer, Differing susceptibilities of Eimeriaacervulina, Eimeria maxima, and Eimeriatenellaoocysts to desiccation. J. Parasitol., 99, 2013, 899–902.
[3]. R.B. Williams,. "Laboratory Tests of phenolic disinfectants as oocysticides against the chicken coccidiumEimeriatenella. Vet. Record, 14 (1), 1997, 447–448.
[4]. R.Z. ABBAS, D.D. COLWELL and J. GILLEARD., Botanicals: an alternative approach for the control of avian coccidiosis. World's Poultry Science Journal, 68, 2012, 203-215.
[5]. L.P.A. Oyen,.Lanneaschimperi(Hochst. ex A. Rich) Engl, In Brink, M. and Achigan-Dako, E.G. (Editors). Prota 16: Fibres/ Plantes afibre[CDRom].PROTA, Wageningen,Netherlands,2010.http://www.database.prota.org/PROTAhtml/lannea%20schimperi_En.htm.
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| Paper Type | : | Research Paper |
| Title | : | Nasal Drug Delivery-A Pre Hospital Therapy in Status Epilepsy-Review |
| Country | : | India |
| Authors | : | Chitra Karthikeyini.S || K.Kavitha |
Abstract: Status epileptics is a brain disorder. It is an important neurological emergency with high mortality and morbidity. it causes loss of cerebral autoregulation and neuronal damage. Prompt and immediate prehospital treatment is required to shorten the duration of seizures. So Parents and care givers needssimple ,safe.,efficaciousprehospitaltherapy. As per parents and care givers needs and consideration of severity of status epileptics and complexity of brain this review has been focused on intra nasal route as a prehospital therapy.......
Keywords: Status epileptics ,Intranasal drug delivery, Brain targeting, anticonvulsant drug, Absorption enhancer, Blood Brain Barrier
[1]. Tiege X, Laufs H, B 252oyd S, et al. EEG-fMRI in children with pharmacoresistant focal epilepsy. Epilepsia.2007;48:385–389. (PubMed)
[2]. P.P.Nair ,J.KalitaMisra UK Status epilepticuswhy,what and how .Journal of post graduated medicine ,2011,57,242 doi:10.4103/0022-3859.81807
[3]. Edward M et al ,New management strategies in the treatment of status epilepticus,Dept of Neurology,Mayo Clinic Pro 2003,78,508-518.
[4]. WermelingDP,Intranasal delivery of antiepileptic medication for treatment of seizures,Neurotherapeutics,2009,Apr.6(2)352-358 doi:10.1016/j.nurt.2009.01.002
[5]. Ayseulgey et al,Nasal and buccal treatment of midazolam in epileptic seizures in paediatrics ,Clin.Med insights paediatrics ,2012,6 :51-60.doi:10.4137/cmped.58330
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| Paper Type | : | Research Paper |
| Title | : | Isolation and Screening of L-asparaginase and L-glutaminase Producing Bacteria and their Antimicrobial Potential from Environmental Sources |
| Country | : | India |
| Authors | : | Jennifer Emelda Edward Arockia Raj || Athmanathan Baskaran || Subbaraj Dinesh Kumar || Indrajith Sureka || Meganathan Velmurugan || Karuppannan Sathiyamurthy |
Abstract: Microbes are greatest sources for the bulk production of L-asparaginase and L-glutaminase for its bio-medical applications. Bacteria from terrestrial and marine habitats have long been recognised as an organism of antibiotic producers. L-asparaginase and L- glutaminase is an enzyme produced by various microorganisms which are currently used for the treatment of leukemia, in the food industry as a flavour enhancer and also as enzyme biosensors. The aim of this work was to screen L-asparaginase and L-glutaminase producing bacteria from the aquatic and terrestrial environment and their antimicrobial activity......
Keywords: Antimicrobial activity, L-asparaginase, and L-glutaminase bacteria.
[1]. El-Bessoumy, A., sarhan, m, Mansour, J. (2004). Production, Isolation and Purification of L- Asparaginase from Pseudomonas aeruginosa 50071 using solid state fermentation , Journal of Biochemistry and Molecular Biology, 37(4), 387-393.
[2]. Savitri, Asthana N, Azmi W (2003) Microbial L-Asparaginase. A potent anti-tumour enzyme. Indian J Biotechnol 2:184-94.
[3]. Siddalingeshwara K.G., Lingappa K (2003) Production and characterization of L-asparaginase- A tumour inhibitor; International Journal of Pharm Tech Research; 3(1): s 314-319.
[4]. Agarwal A, Kumar S, Veeranki VD (2011) Effect of chemical and physical parameters on the production of L-asparaginase from a newly isolated Serratia marcescens SK-07. Lett Appl Microbiol 52: 307-313.
[5]. Prakasham RS, Hymavathi M, Subba RC, Arepalli SK, Venkateswara RJ, Kavin KP, Nasaruddin K., et al. (2010) Evaluation of theantineoplastic activity of extracellular asparaginase produced by isolated Bacillus circulans. Appl Biotechnol 160: 72-80.
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| Paper Type | : | Research Paper |
| Title | : | Epidemiological Survey of Tonsillitis Caused By Streptococcuspyogenesamong Children in Awka Metropolis (A Case Study of Hospitals in Awka Community, Anambra State) |
| Country | : | Nigeria |
| Authors | : | Okoye, E.L || Obiweluozor, C.J || Uba B.O || Odunukwe, F.N |
Abstract: The epidemiological survey of tonsillitis caused by Streptococcus pyogenes among children in Awka metropolis was carried out using samples from three different hospitals. A total number of 73 throat swabs were collected from children aged between 5weeks - 5 years. Swab sticks were streaked onto Blood agar and MacConkey agar for isolation of the test organism.......
Keywords: Antibiotics,Bacterial isolates,Streptococcus pyogenes,Throat Swabs,Tonsillitis
[1]. Simon, H.B., (2005) Bacterial infections of the upper respiratory tract. American College ofPysicians internal medicine.Volume 2. Published by WebMD Inc
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[4]. Eisenberg, J. (2012) Rheumatic heart disease in the developing world: prevalence, prevention and control. European Heart Journal 4: 122-128
[5]. Patterson, M.J, (2012). Streptococcus. Baron's Medical Microbiology. 4th edition. Chapter 3
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| Paper Type | : | Research Paper |
| Title | : | Anti-Cancer Activities of Crude Extracts from Kenyan Moringa Oleifera Lam and Rauwolfia Caffra against Selected Cancer Cell Lines |
| Country | : | Kenya |
| Authors | : | T. Milugo || L.K. Omosa || B. Owuor || J. Oyugi || J. Ochanda || F. Wamunyokoli |
Abstract: The current study was undertaken to validate the traditional use and determine the safety profiles of Moringa oleifera and Rauwolfia caffra used in Kenya to manage tumors and related ailments. This was achieved by determining the anti-proliferative activities of the active antioxidant extracts (50% methanol in dichloromethane) of Moringa oleifera leaves (MeOH) and Rauwolfia caffra stem bark using crystal violet assay. Human liver (hepatocellular carcinoma, Hep-G2) and muscular (rhabdomyosarcoma, RD) were used as model cell lines and cytotoxicity was assessed using Vero cell lines........
Keywords: Anticancer activities, Hep-G2 cell lines, Moringa oleifera, Rauwolfia caffra, RD cell lines
[1]. J. Ferlay, H.R. Shin, F. Bray, D. Forman, C. Mathers, D.M. Parkin, Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008, International Journal of Cancer, 127(12), 2010. 2893-2917.
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| Paper Type | : | Research Paper |
| Title | : | Incidence of Cardiovascular Diseases In Relation To Age, Gender and Blood Pressure in Abbottabad KPK Pakistan |
| Country | : | Pakistan |
| Authors | : | Warda Baig || Fahad Akhtar || Nodia Shujaat || Bad-e-Saba Jamshaid || Mugheer Pervaiz || Usman shaukat || Hajra Muhammad Sharif || Muhammad Mamoon Iqbal || Fareeha Zahoor || Ayesha Iqbal |
Abstract: Background: Cardiovascular diseases (CVD) are considered to be the foremost basis of mortality and transience in the developing world. CVD risk factors such as diabetes, asthma, anemia, smoking, obesity and the metabolic syndrome, may reverse downward trends in CVD mortality. Methodology:A prospective cross-sectional study was conducted at ATH on patients with CVD. Cross sectional data using constructed Performa which contains essential parameters that are specifically correlated with cardiovascular diseases. Survey based data was collected on daily basis........
[1]. Adeyi O, Smith O, Robles S. Public policy and the challenge of chronic non communicable diseases. World Bank Publications; 2007.
[2]. AL Maliki, W.H., The prevalence of cardiovascular diseases and role of protective measures among hajj pilgrims.1432.Pakistan Journal of Pharmacology, 29, 29-34, 2011.
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[4]. Berry, J.C., Dyer, A., Cai, X., Garside, D.B., Ning, H., Thomas, A., Greenland, P., Van Horn, L., Tracy, R.P., Lloyd-Jones, D.M., Lifetime Risks of Cardiovascular Disease.N Engl J Med. 2012;366,321-329
[5]. Bhatnagar P, Wickramasinghe K, Williams J, Rayner M, Townsend N, The epidemiology of cardiovascular disease in the UK.Heart. 2015 1-8.
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| Paper Type | : | Research Paper |
| Title | : | Controlling Mosquito Populations and Reducing the Risk of Mosquito-Borne Diseases in a Beach Resort of Punta Cana Using Eco-Friendly Technologies |
| Country | : | U.S.A. |
| Authors | : | Thomas Martin Kollars, Jr. || Steven Hatfill || Eric Lewis Kollars || Karl Neidhardt |
Abstract: A new technology to deliver eco-friendly pesticides was developed in order to control mosquitoes, reduce the threat posed by mosquito-borne diseases, and to greatly reduce the amount of pesticides delivered into the environment surrounding hotel environments and in densely populated areas. The ProVector®Mosquito Control Systemis designed to use color as an attractant while delivering an attractant Entobac™ attractant pesticide to target pests........
[1]. International Association for Medical Assistance for Travelors (2016). General Health Risks: Zika Virus, www.iamat.org/country/dominican-republic/risk/zika-virus.
[2]. Kollars, T. M. Jr., P. Kollars, B. Hulsey. (2016). Preventive Medicine: Reducing the Risk to Marine Ports from Invasive Mosquito Species, Zika, Dengue, Chikungunya viruses and Filariasis. Intl Journal of Med (in press).
[3]. Ponlawat1, A., J. Boonsong, and T. M. Kollars, Jr. 2016. Susceptibility 191 of Adult Aedes aegypti and Anopheles dirus to Bait Containing Bacillus thuringiensis israelensis. IOSR J.Pharmacy 6:1-3
[4]. Schilthuis, H. and D. Overbosch (2000). Increase of malaria in the Dominican Republic. Ned Tijdschr Geneeskd 144:385-386.
[5]. Thavara U, A. Tawatsin, P. Phan-Urai, W. Ngamsuk, C. chansang, M. Liu, and Z. Li (1996). Dengue vector mosquitoes at a tourist attraction, Ko Samui, in 1995. Southeast Asian J Trop Med Public Health. 27:160-3.
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| Paper Type | : | Research Paper |
| Title | : | Proposal of Employ of Niacin at Massived Osage for Topical Use in Male Weak Pen Iserection |
| Country | : | Italy
|
| Authors | : | LorenzoMartini |
Abstract: Recentstudiesdemonstratethatpriorapplicationofanemulsioncontainingniacinasvasodilatorfavours subsequentluminoustreatments. Aimsof myresearchisto demonstratethat niacinadministeredtopicallyat strongdosagescanallowvasodilatationof the helicinearteriesofpenis,keepingonaccountthesurfaceareaoftheexposedskinto the drugandthusthe morphologyitselfoftheflaccidpenis,independentlyto theconcentrationanddurationofexposureofthe samevitamin........
Keywords: maleerection,niacin,phallometer,Hatanaka-Morimoto'srule,vasodilatationofhelicinearteriesofpenis.
[1]. DanishPatent PCT/DK2004/000201;Oct,14,2004.Inventors: Flemming Kjaergaar Christensen,Cortex Technology Aps.
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| Paper Type | : | Research Paper |
| Title | : | Central Nervous System in Patches Form for the Sustained Release (Diazepam (Valium) |
| Country | : | India
|
| Authors | : | Shivani Bansal |
Abstract: Transdermal drug delivery devices are becoming increasingly common in the field of advanced pharmaceuticals. There are many forms of TDDS in contemporary pharmaceuticals, but transdermal patches are the most desirable method of testing. The present research was performed to establish matrix style transdermal patches containing Diazepam with 10 percent Propylene Glycol used as a plasticizer which can serve as a chemical enhancer and 10 percent Ethanol is used as a permeation enhancer. The most popular HPMC or EC adhesive is used. Possible drug(API) and polymer interactions have been investigated in FTIR experiments and solubility of inert solvent ingredients. Crafted transdermal patches for diazepam (Valium). Physicochemical properties were analysed. Formulated patches were carefully studied for in vitro permeation and stability. All data is translated into graphs. All the formulated patches demonstrated strong physical consistency. The continuous release behaviour is calculated by the dissolution analysis. In vitro permeation experiments were conducted using the Franz Diffusion Cell.
Keywords: Diazepam, Transdermal patches, Permeation enhancer, in-vitro permeation study, dissolution study, plasticizer diazepam (Valium®).
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