Abstract: The objective of this study was to evaluate the anticonvulsant and sedative effects of seeds of Crossopteryx febrifuga, a Congolese medicinal plant belonging to the rubiaceae family. Two pharmacological test were carried out to evaluate each of its properties, respectively: Picotoxine induced convulsions test (PIC 7.5 mg / kg) and Strychnine induced convulsions test (STR 2.5 mg / kg); the motricity test and the barbiturate sleep potentiation test induced by phenobarbital 50 mg / kg in mice. The results obtained showed that the aqueous extract of the seeds of C. febrifuga at a dose of 200 mg / kg caused a significant increase in the time to onset of the seizures induced by PIC and......
Keywords: Crossopteryx febrifuga, anticonvulsant, sedative, mouse, seed
[1]. Bassoueka D.J., Loufoua B.A.E., Etou-Ossibi A.W., Nsondé-Ntandou., Ondelé, R., Elion-Itou R.D.G., Ouamba J.M. et Abena A.A., (2015), Plantes anticonvulsivantes du Congo, approche ethnobotanique, Phytothérapie, 13 : 298-305.
[2]. Bassoueka D.J., Taiwe Sotoing G., Nsonde Ntandou G.F. et Ngo Bum E., (2016), Anticonvulsant activity of the decoction of Crossopteryx febrifuga in mice, International Journal of Science and Research.
[3]. Ngo Mbum E, Racotinira A, Racotinira S V et al. Effets of Cyperus articulates compared of anticonvulsant compounds on the cortical wedge. J. Pharmacol., 2003; 87: 27–37.
[4]. Ngo Mbum E, Dawack D L, Schmutz M, et al. Anticonvulsant activity of Mimossa pudica. Fitoterapia, 2004; 75: 309–314.
[5]. Salawu O.A., Tijani A.Y., Babayi H., Nwaeze A.C., Ezeonu C.M.J. et Ndukuba M.A., (2011), Gastroprotective effect of Crossopteryx febrifuga in Wistar rats, African Journal of Traditional, Complementary and Alternative Medecine, 8(3): 300-306..
