Abstract: The in-utero exposure to carbamazepine, an anticonvulsant medicine has been shown to perturb the normal morphogenesis of the fetal brain when used in management of maternal conditions. However, the anatomical histomomphological teratogenic effects on quantitative histostereological effects when exposed at different gestation periods and at different doses is not well elucidated. The broad objective of this study was therefore to evaluate the histostereological teratogenic effects of exposure to various doses of carbamazepine on the development of fetal brain when exposed at different gestation periods.
Materials and methods: In conducting the study, a static group experimental study design was adopted. The animal experimentation was carried out at Small Animal Facility for Research and Innovation (SAFARI) animal house while tissue processing for histology and stereological analysis was done in the department of human anatomy......
Keywords: Carbamazepine, Anticonvulsant, Teratogenic, Histostreology
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