Abstract: Ester Based Mud, a Synthetic-Based drilling fluid used in oil and gas exploration within the Niger Delta pose potential risks to terrestrial food chains through bioaccumulation. This study evaluated the sublethal neuromuscular toxicity of synthetic-based drilling fluids in Bushman’s rabbits (Bunolagus monticularis) using biochemical indices. A randomized definitive experiment was conducted with twenty-four rabbits acclimated for fourteen days and subsequently exposed to 0 (control), 300, 500, 700, and 900 mg/L of drilling fluid for twenty-eight days. Brain...
Key word: Bunolagus monticularis, Synthetic Drilling Fluid, Electrolyte, Metabolites, Neuromuscular
[1].
Adeogun, A. O., Fafioye, O. O., & Ibrahim, H. M. (2022). Petroleum-derived contaminants and neurotoxicity in vertebrates: Mechanisms and biomarkers. Environmental Toxicology and Pharmacology, 91, 103816.
[2].
Adeyemi, J. A., Idowu, A. B., & Oyekunle, J. A. O. (2021). Muscle bioenergetics and electrolyte imbalance in animals exposed to environmental pollutants. Toxicology Reports, 8, 1450–1460.
[3].
Allen, D. G., Lamb, G. D., & Westerblad, H. (2008). Skeletal muscle fatigue: Cellular mechanisms. Physiological Reviews, 88(1), 287–332.
[4].
Ben-Ari, Y. (2017). NKCC1 chloride importer antagonists attenuate many neurological and psychiatric disorders. Trends in Neurosciences, 40(9), 536–554.
[5].
Cardoso, E.S., Cançado, R.P., Heitz, C., Gerhardt-de-Oliveira, M., & Estudo, (2010). Exploratorio descritivo do emprego de coelhos brancos da Nova Zelandia (Orytolagus cuniculus) como modelo animal na avaliação dos padroes de crescimento craniofacial. Revista Odonto Cienc. 22(55): 66-71.
