Abstract: Arsenic is one of the naturally present and widely distributed toxicants in ecosystem. It is also produced by anthropogenic activities. As it is present in water bodies mainly, it can easily enter the food chain and finally reach human body. It has very severe carcinogenic and teratogenic effects on physiological systems. Current study focuses on the effect of arsenic on reproductive system. Our electron microscopic studies clearly demonstrate this effect. Nexin-dynein regulatory complex is a component of flagellum of the mammalian spermatozoa. It is mainly involved in regulating motility of spermatozoa......
Key words: Sodium Arsenite, Swiss Albino Mice, Spermatozoa, Nexin-Dynein
[1]. Akane Morohoshi, Haruhiko Miyata, Keisuke Shimada, Kaori Nozawa,Takafumi Matsumura, Ryuji Yanase, Kogiku Shiba, Kazuo Inaba & Masahito Ikawa. 2020. Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is required for sperm flagellum formation and male fertility in mice. PLOS Genetics; Ver 2. https://doi.org/10.1371/journal.pgen.1008585
[2]. Ana Cláudia Ferreira Souza, Sarah Cozzer Marchesi, Rafael Penha Ferraz, Graziela Domingues de Almeida Lima, Juraci Alves de Oliveira & Mariana Machado-Neves. 2016. Effects of sodium arsenate and arsenite on male reproductive functions in Wistar rats. J Toxicol Environ Health A;79(6):274-86.
[3]. Agency for Toxic Substances & Disease Registry (ATSDR). [2019]. Toxicological profile of Arsenic. US Public Health Services, Atlanta
[4]. Cesare Castellini, Evangelia Mourvaki, Barbara Sartini, Raffaella Cardinali, Elena Moretti, Giulia Collodel, Salvador Fortaner, Enrico Sabbioni & Tommaso Renieri. 2009. In vitro toxic effects of metal compounds on kinetic traits and ultrastructure of rabbit spermatozoa. Reproductive Toxicology, Elsevier; 27(1) :46-54.
[5]. Chen H, Liu G, Qiao N, Kang Z, Hu L, Liao J, Yang F, Pang C, Liu B, Zeng Q, Li Y, Li Y. [2019]. Toxic effects of arsenic trioxide on spermatogonia are associated with oxidative stress, mitochondrial dysfunction, autophagy and metabolomic alterations. Ecotoxicol Environ Saf. 2020 Mar 1;190:110063. doi: 10.1016/j.ecoenv.2019.110063. Epub 2019 Dec 14. PMID: 31846860.