Series-2 (Sep. – Oct. 2025) Sep. – Oct. 2025 Issue Statistics
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| Paper Type | : | Research Paper |
| Title | : | Immunomodulatory and Anti-Migratory Effects of Cordia myxa Lectin on MH7A Synoviocytes |
| Country | : | India. |
| Authors | : | Kiran B.K. || Siddesh B.M || Bhanumathi. || Kumaraswamy H.M. || Prabhakar B.T. |
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: | 10.9790/ 264X-1105020110  |
Abstract: The chronic autoimmune disease known as rheumatoid arthritis (RA) is characterized by oxidative stress, synovial inflammation andprogressive joint damage. Lectins produced from plants have shown promise as multi-target immunomodulators. The current work examined Cordia myxa lectin's (CML) anti-inflammatory properties in RA-relevant in-vitro and ex-vivo conditions. The MTT assay was used to purify CML and assess its cytotoxicity in MH7A synoviocytes at doses ranging from 3 to 100 μg/mL. Up to 15 μg/mL, it maintained over 90% viability, but above 30 μg....
Key Word: Cordia myxa lectin; Anti-inflammation; MH7A cells; Migration assay; COX/LOX inhibition; Immunomodulation.
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| Paper Type | : | Research Paper |
| Title | : | Pharmacological Assessment of Anti-anaemic property of chloroform fraction of Cnidoscolus aconitifolius leaves in phenylhydrazine-induced anaemic rats. |
| Country | : | Nigeria |
| Authors | : | Obiajulu Christian Ezeigwe || Ebele Lauretta Iloanya || Ngozichukwuka Immaculata Achara || Onyinye Olivia Obiukwu || Chiamaka Crescentia Okafor |
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: | 10.9790/ 264X-1105021123 |
Abstract: Cnidoscolus aconitifolius is a globally consumed vegetable that has been utilized for its nutritive and medicinal relevance, especially for the treatment of anaemia in some parts of Nigeria. Since the crude extract has been proven to ameliorate anaemic symptoms, this study then aims to ascertain if some of the anti-anaemic properties of C. aconitifolius reside within the chloroform fraction. The crude ethanol extract of C. aconitifolius was fractionated.......
Keywords: Cnidoscolus aconitifolius, anaemia, fractionation, phenylhydrazine, chloroform, Emzoron.
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| Paper Type | : | Research Paper |
| Title | : | 3D Printing in Reconstructive Surgery |
| Country | : | India |
| Authors | : | Nimeesha Chona |
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: | 10.9790/ 264X-1105022435 |
Abstract: Emerging technologies have altered the course of the medicine field in the recent years. Three-dimensional (3D) printing (sometimes referred to as additive manufacturing), has become a well-known technique due to the capacity to create strongly personalized, patient-specific health solutions. Using 3D printing, implants, prostheses and anatomical models (as well as bioengineered tissues) can be fabricated with a high level of precision as precise.....
[1].
Chae, M. P., Rozen, W. M., McMenamin, P. G., Findlay, M. W., Spychal, R. T., & Hunter-Smith, D. J. (2020). Emerging applications of bedside 3D printing in plastic surgery. Frontiers in Surgery, 7, 40. https://doi.org/10.3389/fsurg.2020.00040
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Choi, J. W., & Kim, N. (2015). Clinical application of three-dimensional printing technology in craniofacial plastic surgery. Archives of Plastic Surgery, 42(3), 267–277. https://doi.org/10.5999/aps.2015.42.3.267
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Cubo, N., García, M., Del Cañizo, J. F., Velasco, D., & Jorcano, J. L. (2016). 3D bioprinting of functional human skin: production and in vivo analysis. Biofabrication, 9(1), 015006. https://doi.org/10.1088/1758-5090/9/1/015006
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Jakus, A. E., Rutz, A. L., Jordan, S. W., Kannan, A., Mitchell, S. M., Yun, C., Koube, K. D., Yoo, S. C., Whiteley, H. E., Richter, C. P., & Shah, R. N. (2016). Hyperelastic “bone”: a highly versatile, growth factor–free, osteoregenerative, scalable, and surgically friendly biomaterial. Science Translational Medicine, 8(358), 358ra127. https://doi.org/10.1126/scitranslmed.aaf7704
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Kramer, F. J., Baethge, C., Swennen, G. R., & Dempf, R. (2016). Navigated 3D virtual planning in cranio-maxillofacial surgery: a new standard? Journal of Oral and Maxillofacial Surgery, 74(2), 482.e1–482.e8. https://doi.org/10.1016/j.joms.2015.11.024
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Mogali, S. R., Mohandas, L., & Su, L. (2019). Three-dimensional printing in surgical education: a systematic review. Journal of Surgical Education, 76(1), 256–267. https://doi.org/10.1016/j.jsurg.2018.06.003
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| Paper Type | : | Research Paper |
| Title | : | Construction of a β-Carotene-Producing Pichia pastoris Strain |
| Country | : | China |
| Authors | : | Tao Zheng || Zihan Zhao || Wenhao Sun || Qian Li |
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: | 10.9790/ 264X-1105023640 |
Abstract: In this study, a high-efficiency β-carotene-producing strain was developed using Pichia pastoris GS115 as the chassis organism. Key genes from Xanthophyllomyces dendrorhous—geranylgeranyl pyrophosphate synthase (GGPPxd), phytoene desaturase (CarB), and a bifunctional lycopene cyclase (CarRPY72R) with substrate inhibition relieved—were codon-optimized and integrated into the yeast genome through.......
Keywords: β-carotene; Pichia pastoris; microbial cell factory; synthetic biology; metabolic engineering
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Bogacz-Radomska, L., & Harasym, J. (2018). β-Carotene—properties and production methods. Food Quality and Safety, 2(2), 69-74.
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| Paper Type | : | Research Paper |
| Title | : | Construction of Three Auxotrophic Pichia pastoris Strains |
| Country | : | China |
| Authors | : | Xiaonan Ju || Xunlin Li || Tongtong Dou || Huan Wang || Qian Li |
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: | 10.9790/ 264X-1105024144 |
Abstract: In recent years, non-conventional yeasts with unique stress tolerance and substrate utilization capacity have attracted increasing attention. Among them, Pichia pastoris has emerged as a well-established host for recombinant protein production owing to its compact 9.4 Mb genome, ability to utilize methanol, and excellent high-cell-density fermentation performance. Beyond recombinant proteins, P. pastoris has been widely extended to the biosynthesis of natural products and basic biological research. Its major advantages include stable genomic integration, efficient......
Key words: Pichia pastoris; CRISPR/Cas9; auxotrophic marker; genome editing; non-homologous end joining.
[1].
Ahmad, M., Winkler, C. M., Kolmbauer, M., Pichler, H., Schwab, H., & Emmerstorfer-Augustin, A. (2019). Pichia pastoris protease-deficient and auxotrophic strains generated by a novel, user-friendly vector toolbox for gene deletion. Yeast, 36(9), 557-570. doi: 10.1002/yea.3426.
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Bernauer, L., Radkohl, A., Lehmayer, L. G. K., & Emmerstorfer-Augustin, A. (2020). Komagataella phaffii as Emerging Model Organism in Fundamental Research. Front Microbiol, 11, 607028. doi: 10.3389/fmicb.2020.607028.
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Cai, P., Duan, X., Wu, X., Gao, L., Ye, M., & Zhou, Y. J. (2021). Recombination machinery engineering facilitates metabolic engineering of the industrial yeast Pichia pastoris. Nucleic Acids Res, 49(13), 7791-7805. doi: 10.1093/nar/gkab535.
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| Paper Type | : | Research Paper |
| Title | : | Dynamic Acoustic Gating for On-Demand Ion Selectivity in Nanoporous Graphene Desalination Membranes |
| Country | : | India |
| Authors | : | Riddhi Sonekar || Ritvik Chakka |
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: | 10.9790/ 264X-1105024548 |
Abstract: Nanotechnology has been an area of research in recent years since it is possible to synthesize materials with normal properties at the nanoscale. Among them, silver nanoparticles (AgNPs) are particularly interesting due to their antimicrobial, antioxidant, anticancer, and catalytic properties. Conventional physical and chemical routes used for the synthesis of AgNPs involve the use of harmful chemicals, high energy input, or costly apparatus, thereby posing environmental and safety risks. Due to these limitations, green synthesis using plant extracts has been.....
Keywords- Nanotechnology, Green Synthesis, Silver Nanoparticles (AgNPs), Phytochemicals, Antimicrobial Activity, Biomedical Applications, Environmental Remediation
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