Volume-8 ~ Issue-2
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| Paper Type | : | Research Paper |
| Title | : | Human Systems Biology |
| Country | : | India |
| Authors | : | Bhrugesh P. Joshi, Roshni K. Bhatt, DR. R. Krishnamurthy |
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: | 10.9790/3008-0820105  |
Abstract:Human Systems Biology (HSB) is the pertinence of computational biology to Human health and disease, with scrupulous emphasis on the contrive of cellular, molecular and structural biology. HSB is a relatively new field of network analysis and systems biology. That focuses on the, high quality databases, the analyses of data that are generated in systems biology and network medicine approaches and the generation of testable hypothesis. HSB originally emerged as an ameliorate the drug discovery and development process. However HSB now plays an elaborating paramount role in many areas of proteomics, genomics, metabonomics biophysics and biomedical engineering. HSB can also be applied to new drug invention for pharmaceutical industries.
Keywords: Human disease, New drug application, Whole organ modeling.
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| Paper Type | : | Research Paper |
| Title | : | The Prevalence And Plasmid DNA Mediated Antibiotic Resistance Of Isolates Of Staphylococcus Aureus From Recurrent Furunculosis In University College Hospital, Ibadan Nigeria. |
| Country | : | Nigeria |
| Authors | : | Okunye, Olufemi Lionel, Adeleke, O.E,; Adeyemi, Omokehinde H. |
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: | 10.9790/3008-0820611 |
Abstract: The purpose of this study was to determine the prevalence of recurrent furunculosis in terms of age, gender and genetic basis from infected volunteers in university college hospital Ibadan Nigeria. A total of 102 isolates of Staphylococcus aureus from various anatomical pathological skin lesion were obtained from four hundred biochemically characterized samples. Antibiotic susceptibility profiles and minimum inhibitory concentration of the isolates was determine by Kirby Bauer and broth dilution method. β-lactamase potential of the isolates was determined by iodometric cell suspension methods and plasmid profiles by the use of lystostaphin for lyzing the cell wall. The percentage gender distributions were 46.0% females and 54.0% males. The isolates exhibited the lowest resistance of 11.75% to amoxicillin-clavulanic acid and 55.88% as the highest resistance to tetracycline. Thirty of the isolates possessed β-lactamase in varying degrees out of which 29 were plasmid-borne and 7.0 had multiple plasmid DNA of 2-4 copies, ranging between 2.20 and 23.10 kb. The resistance elicited by the strains evident in the Minimum Inhibitory Concentrations of the selected antibiotics and the associated R-plasmid encoded β-lactamase recorded accounted for the recurrent furunculosis which was found to vary among gender and age groups.
Keywords: Antibiotic resistance, Plasmid DNA, Recurrent furuncle, Staphylococcus aureus.
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| Paper Type | : | Research Paper |
| Title | : | Evaluation of Selected Heavy Metals and Macronutrients Status of 10 Medicinal Plants from Nigeria |
| Country | : | Nigeria |
| Authors | : | Ibironke A. Ajayi, Rotimi A. Oderinde, Adewale Adewuyi, Joseph I. Uponi |
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: | 10.9790/3008-0821217 |
Abstract: Ten important herbal plants from the South-west of Nigeria were analyzed for their heavy metal (K, Na, Ca, Mn, Mg, Cu, Fe, Zn, Pb and P) and macro-nutrient status using an atomic absorption spectrophotometer. The most prevalent heavy metals were K (162 – 524 mg/mL) and Ca (102 – 472 mg/mL) followed by Mg (48.10 – 136.00 mg/mL) and Na (3.51 – 10.10 mg/L). The highest level of K (524.00 ± 5.70mg/mL) and Ca (472.00 ± 1.44 mg/mL) were found in Senna alata and Senna podocarpa, respectively. Out of all the plants, Dissotia rotundifolia had the highest concentrations of Mg (136.00 ± 0.28 mg/mL) and Na (10.10 ± 0.03 mg/mL). The results showed that the level of Cu (0.65 – 1.48 mg/mL) and Zn (2.40 – 6.77 mg/mL) found in the herbal plants were much lower than the reported range of the elements in agricultural products.
Keywords: medicinal plants, digestion, macronutrient status, agricultural products
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| Paper Type | : | Research Paper |
| Title | : | Bacteriological and Physicochemical Analyses of Borehole and Well Water Sources in Ijebu-Ode, Southwestern Nigeria |
| Country | : | Nigeria |
| Authors | : | O. O. Bello, A. Osho, S.A. Bankole, T. K. Bello |
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: | 10.9790/3008-0821825 |
Abstract: An investigative study was carried out to determine the bacteriological and physicochemical qualities of borehole and well water samples in Ijebu-Ode, Southwestern Nigeria. Ten water samples each of borehole and well water sources were collected within the geographical location. Physicochemical parameters were determined using standard methods. The total bacterial count was determined by pour plate technique and total coliform determined using 3-3-3 regimen. Identifications of isolates were done using standard methods. The colour and turbidity of water samples were within the normal range. Eight genera of bacteria which include Escherichia coli, Klebsiella sp, Salmonella sp, Shigella sp, Enterococcus sp, Proteus sp, Pseudomonas aeruginosa and Staphylococcus aureus were isolated from the water samples. Total bacterial count in borehole and well waters sampled ranged from zero to 2.5 x 102 cfu/ml and zero to 8.1 x 102 cfu/ml, respectively. The total coliform count of the borehole waters analyzed ranged from zero to 16 MPN index of coliform/100 ml while that of well waters ranged from 16 to 1100 MPN index of coliform/100 ml of the water samples. All borehole water samples had zero faecal coliform count while in well water samples, count ranged from zero to 4.1 x 102 cfu/ml. It was concluded that not all borehole waters are safe for consumption and well waters were of poorer bacteriological qualities indicative of health risk to the inhabitants of the geographical location.
Keywords: Borehole, bacteria, coliforms, well, water, quality
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