Volume-6 ~ Issue-5
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| Paper Type | : | Research Paper |
| Title | : | Antimicrobial Screening of Vanga Vennai and Mathan Thailam for Diabetic Foot Ulcer |
| Country | : | India |
| Authors | : | Elangovan.S, Jeeva gladys.R, Kalai arasi.R, Mubarak.H, Velpandian V. |
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: | 10.9790/3008-0650105  |
Abstract: Siddha medicine is one of the ancient traditional science which is specialized in external medicines (Pura marunthukal). Diabetic patients develop foot ulcers as a major complication of Diabetes mellitus due to high susceptibility to infection which often leads to amputation. Diabetic foot infection is a combination of both aerobic and anaerobic organisms. Thus there is a need for effective and selective treatment strategies. This article focuses on antimicrobial screening of Vanga vennai (VV), Mathan Thailam (MT) and combination of both (VV+MT) which are the classical Siddha preparations. The methodology involved in the study is Agar well dilution method for anti microbial activity. Thus it paves a new way in treating infections of Diabetic foot ulcers. This preliminary study reveals these Siddha formulations as an effective therapeutic strategy for the management of Diabetic foot ulcer.
Keywords: Anti microbial activity, Diabetic foot ulcer, Mathan thailam, Siddha medicine, Vanga vennai
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| Paper Type | : | Research Paper |
| Title | : | Role of soluble urokinase plasminogen activator receptor (suPAR) as prognosis markers of neonatal sepsis |
| Country | : | Indonesia |
| Authors | : | Retno Nurhayati, Tri Yudani Mardining Raras , Lintang Kawurjan |
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: | 10.9790/3008-0650614 |
Abstract: Biological marker suPAR was used in many pathological conditions, including infection. suPAR was correlated with the severity of sepsis. The purpose of this study to determine levels of suPAR infants with risk of infection as a prognostic indicator for sepsis. Groups of infants with the risk of infection (n = 43) were followed prospectively on days 0, 3rd and 7th and observed for the incidence of sepsis compared to the control group (n = 10). suPAR was measured by ELISA and the course of infection measured by clinical criteria. Results suPAR day 0, 3 and 7, displayed in the form of bloxpot and AUC as prognostic power. suPAR control levels 9.32 ng / mL, sepsis cutoff 15, 41 ng / mL and AUC of 80.3% [95% CI 65.7%, 94.9%, p = 0.00]. Graph shows ROC AUC sepsis suPAR day 0, the 3rd and 7th respectively 61.9%, 66.6% and 94.4%. Sepsis with improved output 16.53 ng / mL and worsening 22.19 ng / mL and AUC of 80.8% [95% CI (0.62 to 0.99), p = 0.02]. suPAR levels was increased in neonatal sepsis patients. suPAR could be used as a prognostic factor for neonatal sepsis.
Keywords -Urokinase plasminogen activator receptor, Neonatal sepsis.
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| Paper Type | : | Research Paper |
| Title | : | Optimization of Cultural Parameters for Cellulase Enzyme Production from Fungi Species Isolated From Degradation Corn Cob |
| Country | : | Nigeria |
| Authors | : | Bamigboye, O. O. |
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: | 10.9790/3008-0651519 |
Abstract: Cellulalytic fungi synthesize cellulose enzyme for biodegradation of cellulose. This depends on various condition which include the source f isolation. This study was designed to determine the optimum condition necessary for cellulose production by fungi. Cellulose activities at different temperatures, pH and nitrogen sources by Rhizopus oryzae Aspergillus niger; A. flams, P. expansum and A. oryzae in liquid medium was studied and cellulose enzyme assay carried out by dinitrosalicylic acid method. All the fungal isolates have their highest cellulose activity at 400c except Penicillium expansum whose highest value of 1.28mg/ml was obtained at 320c. Cellulase produced 6m was found to be highest in all the isolate at pH 4.0 exception P expansum which occur at pH 5.5 (1.21mg/ml). The highest value e1.45mg/ml was obtained in A niger. Highest cellulose activity for A. niger, A. oryzae & P. expansum occurred in peptone. The study shows the need to determine the best physiological condition that allow for the optimal cellulose activity of fungal isolate. This will enhance their enzyme production.
Key Word: Cellulase, fungi, pH, Nitrogen, temperature
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