Abstract: Neurodegenerative disease is a term applied to a variety of conditions arising from a chronic breakdown and deterioration of the neuronswhich is associated with oxidative stress. Abrusprecatorius are used for therapeutic purposes because they contain several active substances that exhibit antioxidant properties.Thein-vitro anticholinesterase and antioxidant properties of the methanol extract of the leaves and seeds of Abrusprecatoriususing two types of extraction techniques; soxhlet and cold maceration was investigated in this study. The anticholinesterase property was evaluated using Ellman's method while antioxidant property was determined by evaluating the....
Key Word: Anticholinesterase, Antioxidant, Abrusprecatorius, Neurodegenerative.
[1]. Poljsak B., Šuput D., and Milisav I., "Achieving the balance between ROS and antioxidants: when to use the synthetic antioxidants," Oxidative Medicine and Cellular Longevity, vol. 2013, Article ID 956792, 11 pages, 2013.
[2]. Alam M.N, Bristi N.J, Rafiquzzaman M. Review on in vivo and in vitro methods evaluation of antioxidant activity. Saudi Pharm J. 2013;21(2):143-52.
[3]. Singh U. and Jialal I., "Oxidative stress and atherosclerosis," Pathophysiology, vol. 13, no. 3, pp. 129–142, 2006.
[4]. SasK., Robotka H., Toldi J., and Vécsei L., "Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disorders," Journal of the Neurological Sciences, vol. 257, no. 1-2, pp. 221–239, 2007.
[5]. Smith M. A., Rottkamp C. A., Nunomura A., Raina A. K., and Perry G., "Oxidative stress in Alzheimer's disease," Biochimica et Biophysica Acta, vol. 1502, no. 1, pp. 139–144, 2000.
