Series-1 (Jan-Feb 2019)Jan-Feb 2019 Issue Statistics
- Citation
- Abstract
- Reference
- Full PDF
| Paper Type | : | Research Paper |
| Title | : | Hepatoprotective Activities of Girang Leaf Ethanol Extracts (Leea angulata Korth. Ex Miq) on Wistar Rats Induced by Paracetamol |
| Country | : | |
| Authors | : | Ni Luh Rustini || Ida Bagus Putra Manuaba || Bagus Komang satriyasa |
 |
: | 10.9790/3008-1401010105  |
Abstract: Paracetamol is an analgesic and antipyretic drug that has a toxic effect when it is used with excessive doses. The toxicity of paracetamol is caused by the formation of NAPQI reactive metabolites and paracetamol inducing the formation of free radicals which can cause liver cell damage. This study aims to test the hepatoprotective activity of ethanol extract of girang leaves (Leea angulata Korth. Ex Miq) in male white rats of the Wistar strain.Acute liver damage was done by inducing paracetamol at a dose of 750 mg / kg BW. Ethanol extract of girang leaves was given at a dose of 50, 100, 200, and 400 mg/kg per oral for 14 days. Liver biochemical parameters (ALT activity) of rat............
Key words: hepatoprotective effect, paracetamol, ethanol extract of girang leaves
[1]. Akhlaghi, M. and Bandy, B. 2009. Mechanisms of Flavonoid Protection Against Myocardial Ischemia-Reperfusion Injury. Journal of Moleculer and Cellular Cardiology. 46: 309-317
[2]. Akther, N., Shawl, A. S., Sultana, S., Chandan, B. K. 2013. Hepatoprotective Activity of Marrubium vulgare Against Paracetamol Induced Toxicity. Journal of Pharmacy Research 7 (7): 565-570
[3]. Akhter, S., Rahman, M. A., Aklima, J., Hasan, M. R., Chowdhurty, K. H. 2015. Antioxidative Role of Hatikana (Leea macrophylla Roxb) Partially Improve the Hepatic Damage Induced by CCl4 in Wistar Albino Rats. Biomed Res Int. 15 (1): 1-14
[4]. Alam, J., Mujahid, M., Badruddeen, Jahan, Y., Bagga, P., and Rahman, M. A. 2017. Hepatoprotective Potential of Ethanol Extract of Aquilaria agallocha Leaves Against Paracetamol Induced Hepatotoxicity in SD Rats. Journl of Traditional and Complementary Medicine. 7 (1): 9-13
[5]. Begum, M., Kumar, S., Balakris, S. 2015. Antioxidant and Hepatoprotective Activity of Andrographis paniculata Against Acetaminophen (Paracetamol) Induced H Rats. International Journal of Current Research. 3 (12): 864-868
- Citation
- Abstract
- Reference
- Full PDF
| Paper Type | : | Research Paper |
| Title | : | L-Ergothioneine Supplement Protect Testicular Functions In Cisplatin-Treated Wistar Rats. |
| Country | : | Nigeria |
| Authors | : | Ayobami DARE || Olugbemi Tope OLANIYAN || Maimuna Abdu SALIHU || Kehinde Linus ILLESANMI |
|
: | 10.9790/3008-1401010613 |
Abstract: The present study was designed to investigate the role of L-ergothioneine supplement against cisplatin-induced reproductive toxicity in male wistar rats, regarding the antioxidant and cytoprotectant property of this supplement, and redox indices generated by cisplatin administration during administration.Twenty adult male wistar rats randomly divided into four groups (n=5) were used in this study and subjected to treatment as follows; Group I (control) received 10mL/kg distilled water for 14days; Group II (Cis alone) received a single dose........
Key words: L-ergothioneine, cisplatin, antioxidant, testis
[1]. Aksu, EH, Akman, O, Ozkaraca M, Omur AD, Ucar O (2015): Effect of Maclura pomifera extract against cisplatin-induced damage in reproductive system of male rats. Kafkas Universitesi Veteriner Fakultesi Dergisi. 21:397–403.
[2]. AldemirM,OkuluE,KösemehmetoğluK, Ener K, Topai F, Evigren O, Gurleyik E, Avci A (2014): Evaluation of the protective effect of quercetin against cisplatin‐induced renal and testis tissue damage and sperm parameters in rats. Andrologia. 46 (10), 1089-1097.
[3]. Amin AA, Hamza EA (2006): Effects of Roselle and Ginger on cisplatin-induced reproductive toxicity in rats. Asian Journal of Andrology. 8(5), 607–612.
[4]. Aruoma OI, Spencer JP, Mahmood N (1999): Protection against oxidative damage and cell death by the natural antioxidant ergothioneine. Food and Chemical Toxicology. 37(11):1043-53. [5]. Askari A, Melville DB (1962): The reaction sequence in L-Ergo biosynthesis: hercynine as an intermediate. Journal of Biological Chemistry. 237:1615–8
- Citation
- Abstract
- Reference
- Full PDF
| Paper Type | : | Research Paper |
| Title | : | Role of Cinnamon Extract in the Protection against Amoxicillin/Clavulanate-Induced Liver Damage in Rats |
| Country | : | Egypt |
| Authors | : | Wafaa M. El-Kholy || Faried A. E. Hemieda || Ghada M. Elabani |
|
: | 10.9790/3008-1401011421 |
Abstract: Amoxicillin/clavulanate (AC), which is effectively used in the treatment of several number of bacterial infections, may cause hepatotoxicity. Cinnamon extract contains natural products which showed antioxidant, anti-inflammatory and anti-bacterial properties. In the present study, two doses of AC, therapeutic (30 mg/kg) and double therapeutic (60 mg/kg), were orally given to rats alone or in combination with cinnamon (200 mg/kg) for 10 consecutive days, to test the potential protective impact of cinnamon extract against AC-induced hepatic injury. Obtained results showed significant increases in serum levels of alanine aminotransferase (ALT), aspartate aminotransferase(AST),.......
Key words: Amoxicillin/clavulanate, cinnamon, liver, oxidative stress, antioxidants
[1]. Finlay J, Miller L, Poupard J A. A review of the antimicrobial activity of clavulanate. J. Antimicrob. Chemother. 2003; 52: 18-21.
[2]. Labia R,Peduzzi J. Kinetics of beta-lactamase inhibition by clavulanic acid. Biochem Biophys Acta. 1978; 526: 572-579.
[3]. Larrey D, Vial T, Micaleff A , Babany G, Morichau-Beauchant M, Michel H, Benhamou J P. Hepatitis associated with amoxycillin-clavulanic acid combination report of 15 cases. Gut. 1992; 33: 368-371.
[4]. Cars O, Molstad S N,Melander A. Variation in antibiotic use in the European Union. Lancet. 2001;357: 1851-1853.
[5]. Stricker B H, Van den Broek J W, Keuning J et al. Cholestatic hepatitis due to antibacterial combination of amoxicillin and clavulanic acid (augmentin) Dig Dis Sci. 1989; 34: 1576–1580.
- Citation
- Abstract
- Reference
- Full PDF
| Paper Type | : | Research Paper |
| Title | : | Caesalpinia Crista Seed Exhibits Strong Anticoagulant and Antiplatelet Activity |
| Country | : | India |
| Authors | : | Chandramma Srinivasa || Sharath Kumar M Nandish || Jayanna Kengaiah || Chethana Ramachandraiah || Ashwini Shivaiah || Devaraja Sannaningaiah |
|
: | 10.9790/3008-1401012230 |
Abstract: Caesalpinia Crista Seeds stores robust phytochemicals responsible for several therapeutic efficacy, hence it has been using from ancient time in the folk medicine. Although, researchers putting effort to validate its stored health benefits, its role in thrombosis was least explored. Thus, current study investigate the anticoagulant, antiplatelet and clot lysis efficiency of Caesalpinia Crista Seed Aqueous Extract (CCSAE). The protein blue prints of CCSAE revealed similar banding pattern from 15-200 kDa on 10 % SDS-PAGE suggests that CCSAE reserves only monomeric proteins. CCSAE exhibited proteolytic activity by degrading casein and gelatin with the specific activity of 0.160.......
Key words: CCSAE, protease, anticoagulant, antiplatelet, clot lysis.
[1]. Sanjeev Palta, Richa Saroa, and Anshu Palta. Overview of the coagulation system. Indian J Anaesth 2014;58(5): 515–523.
[2]. Anne-Celine Martin, Bernard Le Bonniec, Anne- Marie Fischer, Catherine Marchand-Leroux, Pascale Gaussem, Charles-Marc Samama, et al. Evaluation of recombinant activated factor VII, prothrombin complex concentrate, and fibrinogen concentrate to reverse apixaban in a rabbit model of bleeding and thrombosis. International Journal of Cardiology 2013;168:4228-4233.
[3]. Norbert H. Hauel, Herbert Nar, Henning Priepke, Uwe Ries, Jean-Marie Stassen, Wolfgang Wienen, et al.Structure-Based Design of Novel Potent Nonpeptide Thrombin Inhibitors. J. Med. Chem 2002;45 (9):1757–1766.
[4]. M.Nandish SK, Kengaiah J, Ramachandraiah C, Shivaiah A, Chandramma, Girish KS, et al. Anticoagulant, antiplatelet and fibrin clot hydrolysing activities of flax seed buffer extract.Phcog Mag 2018;14:S175-83.
[5]. Sowmyashree G, Bhagyalakshmi M, Girish KS, Kemparaju K, Manohar Shinde, Devaraja S, et al. Anticoagulant and antiplatelet activities of jackfruit (artocarpus heterophyllus) seed extract. Int J Pharm Pharm Sci, Vol 7, Supple 1, 187-191..