iosr-JDMS   Volume-5 ~ Issue-2

Abstract: To compare the effects of single dose of two oral medication following single visit root canal therapy in teeth with irreversible pulpitis MATERIALS AND METHODS: 30 patients who reported to KVG dental college sullia, seeking treatment on which single visit RCT was performed . In this double blind study anterior or premolar teeth with irreversible pulpitis without any signs and symptoms of irreversible pulpitis were selected divided into 3 groups randomly. A control group without any medication and two groups receiving a single dose of E-90 and Movon-p respectively immediately after the root canal therapy the intensity of pain was recorded on a 10 point VAS for upto 24hr post operatively. RESULTS :E-90 Etoricoxib-90 (group 1) was found to be clinically significant at 10% more compared to the other two groups in the reduction of post operative pain . (Movon-p) wasmore effective compared to the control group where no medication was given CONCLUSION: A single dose of E-90 considerably reduced thepost operative pain compared to the other two groups taken immediately after the after the RCT of teeth with irreversible pulpitis. Keywords:Irreversible pulpitis, single visit root canal therapy, postoperative pain,analgesics,periapical lesion.

[1] Effects of three oral analgesics on post operative pain following root canal preparation : A controlled clinical trail. IEJ 45 76-82, 2012.

[2] Etoricoxib for arthritis and pain management TherClin Risk Manag. 2006 March; 2(1): 45–57.

[3] preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2. J PharmacolExp Ther.2001;296:558–66.

[4] Characterization of etoricoxib, a novel, selective COX-2 inhibitor. J ClinPharmacol. 2003;43:573–85.

[5] The COX-2 inhibitor etoricoxib did not alter the anti-platelet of low dose aspirin in health in healthy volunteers [abstract] Arthritis Rheum. 2001;44(Suppl 9):S135. 498.

[6] Pharmacokinetics of etoricoxib in patients with renal impairment.JClinPharmacol. 2004 Jan;44(1):48-58

[7] To evaluate efficacy and safety of fixed dose combination of aceclofenac + paracetamol + thiocolchicoside (acenac-MR) in the treatment of acute low back pain. J Indian Med Assoc. 2012 Jan;110(1):56-8

[8] Treatment of chronic low back pain with etoricoxib, a new cyclo-oxygenase-2 selective inhibitor: improvement in pain and disability--a randomized, placebo-controlled, 3-month trial. J Pain. 2003 Aug;4(6):307-15

[9] COX-2 Selective Inhibitors in the Treatment of Arthritis: A Rheumatologist Perspective Current Topics in Medicinal Chemistry, Volume 5, Number 5

Abstract: The present study was carried out to find out frequency of chromosomal abnormalities & contribution of environmental, occupational factors in cases of male infertility. 70 males referred for complaints of infertility were included in the present study. The study was carried out in the following steps. 1) Selection of patients 2) Clinical examination of patients 3) Collection of blood and karyotyping 4) Photomicrography 5) Data tabulation and Analysis & 6) Collection of buccal smear for Sex Chromatin Study. Cytogenetic analysis of the infertile males revealed that chromosomal abnormalities were present in 9 patients (12.85%). Among the chromosomal abnormalities, Numerical abnormalities were present in 6 patients (8.57%) and Structural abnormalities were present in 3 patients (4.28%). Among the Numerical abnormalities, most common were 47, XXY(2) and 46,XX(2). Mosaicism i.e. 46,XY(20%)/47,XXY(80%) was seen in one patient. One patient showed a karyotype of 47,X,i (Xq)Y. Among the 3 patients with structural abnormalities, one patient showed a 45,XY,-22 t (14/22) karyotype, one patient showed 46,XY, inv(9) and one patient showed 46,XY, large Y.

Key Words: Karyotype, Chromosome, Infertility

[1] Abdelmoula NB., Amouri A., Portnoi MF., Saad A., Boudawara T., Nabil Mhiri M., Bahloul A., Rebai T. (2004). 'Cytogenetic and Flourescent insitu hybridization assessment of mosaicism in Klinefelter syndrome.' Ann Genet , 47 (2):163–75.
[2] Ali, Mahmood and Prabhakara MG., Babu M., Bajaj V., ManJunath GB., Vasan SS., Prasanna Kumar KM., Kumar Arun (2005). 'Cytogenetic and molecular analysis of infertile males.' :79
[3] Alkhalaf M., Varghese L., Muharib N. (2002). 'A Cytogenetic study of Kuwaiti couples with infertility and reproductive disorders: short arm deletion of chromosome 21 is associated with male infertility.' Annales de Genetique. 45(3):147–9.
[4] Ambasudhan R., Singh K., Agarwal J., Singh S., Khanna A., Sah R., Singh I., Raman R. (2003). 'Idiopathic cases of male infertility from a region in India show low incidence of Y-Chromosome microdeletion.' J. Biosci. 28(5):605 -612.
[5] Badovinac A., Tomljanovic AB., Starcevic N., Vlastelic M., Randic L. (2000). 'Chromosome studies in patients with defective reproductive success.' American Journal of Reproductive Immunology. 44:279–83.
[6] Baschatt AA., Kupker W., Hasani S., Diedrich K., Schwinger E. (1996). 'Results of Cytogenetic analysis in men with severe subfertility prior to intracytoplasmic sperm injection.' Hum. Reprod. 11(2):330–3.
[7] Carp H, Feldman B, Oelsner G, Schiff E (2004). Parental karyotype and subsequent live births in recurrent miscarriage. Fertility sterility, Vol 81, No 5: 1296 -1301.
[8] Duzcan F., Atmaca M., Cetin G., Bagci H. (2003). 'Cytogenetic studies in patients with reproductive failure.' Acta Obstet Gynecol Scand.82:53–56.
[9] ESRE Capri Workshop Group (2004). 'Diagnosis & management of the infertile couple: missing information 10(4): 295-307.
[10] Forejt J. (1974) 'Nonrandom association between a soecific autosome & the X chromosome in meiosis f the male mouse-possible consequences of homologous centromere separation.' 13:241-48.

Abstract: Objective:Available literatures on pattern of adult mortality in accident and emergency (A and E) department of health institutions in many developing countries have been virtually restricted to centres in urban areas. This study aimed at highlighting the basic demographic patterns, the frequency and causes of death in a centre in a rural area of a developing country. Methods:A retrospective analysis of patients' records admitted in A and E department of the Federal Medical Centre Ido Ekiti, Ekiti State, Nigeria over a period of 2yearsfrom January 2011 to December 2012 was carried out. Analysis of data was done with simple descriptive statistics using Statistical Packaging for Social Science (SPSS Inc. Chicago IL) version 16. Results:A total number of 3162 patients attended the A and E department during the study period and there were 122 deaths. Male mortality was 76(62.0%) while female mortality was 46(38.0%) with male to female ratio 1:7:1. The age range was 15 – 87years with mean of 52.04 + 18.70years. More deaths occur in young and middle aged adults (70.4%). Deaths from non-communicable diseases (80.3%) were higher than that from communicable diseases (19.7%). The most common causes of deaths from the former were stroke and road traffic accident, while from the latter were sepsis, HIV/AIDS and tuberculosis in decreasing order. Conclusion:The commonest cause of death in adults is non-communicable disease at the prime productive age, worse in males than females. Many causes of deaths obtained in this report were comparable to what was obtained in urban centres except road traffic accident with lesser frequency and communicable diseases with higher frequency in rural centres.

Key words: Mortality, Accident, Emergency, Rural, Developing country.

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