Volume-6 ~ Issue-2

Abstract: Most Polymers do not possess natural intrinsic properties that will be enough for them to be used as semi- conductors. In the world trend of industrial growth where polymers seem to be replacing all semi-conductors because of their availability, durability, recyclability and reduced cost, attention is being strongly given to their improvement them for this essential function hence the need for this research.Eight samples each of four polymers; polyethylene (PE), polystyrene (PS), poly propylene (PP),nylon 66 were prepared by doping with different concentrationsof graphite to enhance their electrical and thermal conductivities, considering the fact that they are of different intrinsic properties. The samples were testedfor their electrical and thermal conductivities.It was evident that as the concentration of the graphite dopantincreases, the electrical and thermal conductivities of all the polymers increased although not at the same rate.The most interesting fact is that all polymers that showed highly favorable results in electrical conductivity, showed the least for thermal conductivities which can be attributed to their intrinsic properties.

Key words: polymers, doping, graphite, thermal conductivities, electrical conductivities.

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Abstract: Major process related unknown impurity associated with the synthesis of Hydralazine hydrochloride bulk drug was detected by high performance liquid chromatography (HPLC) and was subjected to high resolution accurate liquid chromatography mass spectroscopy (HR/AM-LCMS) for identification. The proposed impurity was isolated from Hydralazine hydrochloride active pharmaceutical ingredient (API) by preparative chromatographic method and was injected on HPLC for comparison of retention time with that of the unknown process related impurity in Hydralazine hydrochloride. The molecular ion peak of preparatively isolated impurity and that of unknown process related impurity in Hydralazine hydrochloride were compared for confirmation. The postulated structure was unambiguously confirmed with the help of HR/AM- LC MS/MS, NMR and FTIR data proposed to be 1-(2-phthalazin-1-ylhydrazino)phthalazine (Hazh Dimer). This impurity of Hydralazine hydrochloride is not been previously reported. A rapid Acquity H-class gradient method with runtime of 15.0min was developed for Quantitation on Unisphere Cyno column and validated for parameters such as accuracy, precision, linearity and range, robustness. The LOD and LOQ of method were 0081% and 0.0246% respectively.

Keywords: Acquity UPLC H-class, FTIR, Hydralazine hydrochloride, , HPLC, , HR/AM-LCMS, NMR, , structural elucidation

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Abstract: Various substituted Triazole-Thiol containing different functional group have been synthesized by microwave method. The title product 1-[(3H-indol-2-ylamino) methyl]-4-phenyl-4, 5-dihydro-1H-1, 2, 4-triazole-3-thiol is synthesized by using amino benzothiazole. The final structures have been established on the basis of their chemical analysis and spectral data. All micro-wave synthesized compounds results into good yield as compared to conventional method of which fluoro substituted compound shows maximum yield.

Keyword: Benzothiazole, 1,2,4-triazole,Microwave irradiation etc

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Abstract:Ageratum conyzoides leaves have afforded six compounds which were identified as tritriacontane, henitriacontane, 23-pentatetraacontanone, 3,4,-seco-lup- 20 (29)-en-3-OMe, 3°butyl triacosanoate and methyl tetracosanoate. All are being reported first time from this plant. The different fractions viz. hexane, benzene, ethyl acetate and methanol Ageratum conyzoides leaves were tested for their plant growth inhibitory activity against germination of radish seeds. The percent growth inhibition of radish seeds by different fractions are being reported in this paper.

Key words: Leaves, Ageratum conyzoides, Chromatography, IR, 1HNMR

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