Volume-4 ~ Issue-6

Abstract: A green, safer , efficient , eco-friendly approach for the synthesis of novel compounds which reveal biological and spermicidal activity. The nature of the pharmacophore decides the physiological reactivity of the compound.

Keywords: Microbial, Microwave assisted, Solvent free, Spermicidal activity, Structure-activity relationship

[1] M.Jida, R.Deprez-Poulain, S Mlaguim, P.Roussel, F.Agbosson-Niedercorn, B.Dprez and G.Laconde, Green Chemistry,12,2010,961 [2] S.Sharma, A.Sharma and H.Madam, Indian J.Hetrocyclic Chem,19,2010,337

[3] S.Sharma, R.Jain, V.Sharma and C.Chawlal, J.Indian Chem.Soc,90,2013,221

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Abstract: The chromatographic behaviour of some cephalosporins has been studied on synthetic stannic arsenate layers using citrate and borate buffers as mobile phases. Several ternary and quaternary separations have been achieved. The utility of these separations has been demonstrated for estimation of cephalosporins in blood serum from patients.This method used is simple, rapid ,reproducible and can also be applied in the separation and determination of cephalosporins in other biological samples. The limit of detection was found to be 0.20 μg/l.

KeyWords: TLC, Cephalosporins, Stanic arsenate

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Abstract: Model using Iraqi limestone as an adsorbent has been investigated. The influences of equilibrium time, limestone dosage, limestone particle size, pH of solution, adsorption isotherms and temperature on adsorption performance have been experimentally verified by a batch method. The adsorbent used in this study exhibited a good adsorption potential at initial pH 10, temperatures 28ºC, particle size 75 μm, limestone dosage 0.1g for equilibrium time 140 min. The removal efficiency and distribution coefficient have also been determined for the adsorption system as a function of dosage of the adsorbent. The experimental results are described by Langmuir and Freundlich isotherm models. Experimental results show that the kinetic model of pseudo-second order provided a good description of the whole experimental data more than the kinetic of the Lagergren-first order.

Keyword: Batch adsorption, Methyl Violet, Thermodynamics and Kinetic models.

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Abstract: Solution Chemistry of some bivalent metal ions (viz. CoII , NiII ,CuII ,ZnII ) with β-amide α-aminosuccinate (Asparagine)/ α-aminoisoverate( Valine ) (A) and 5-methyl 2,4- dioxopyrimidine ( Thymine ) (B)ligands have been analyzed. Formation constant of quaternary metal complexes and complexation equilibria at 30±1ºC and at constant ionic strength (I=0.1M NaNO3 ) have been explored potentiometrically. Formation of quaternary species in addition to hydroxyl, protonated, binary and ternary species have been reported. Overall formation constant have been evaluated using SCOGS computer program.Species distribution curves of complexes have been plotted as a function of pH to visualize the equlibria system and was refined using ORIGIN program.The metal ligand formation constant of MA,MB,MAB and M1M2AB type of complexes follow Irving William order. The order of stability constants of quaternary systems have been observed as: Cu – Ni > Cu –Zn > Cu–Co > Ni – Zn > Ni – Co > Co –Zn. Solution structures of metal complexes with said ligands have been compared and discussed.

Keywords: Multinuclear complexes/ SCOGS/ Valine / Asparagine/ Thymine

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