Volume-11 ~ Issue-11 ~ November-2018

Abstract: Antibacterial activity was assayed for the title compounds against Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Klebsiella pneumoniae by agar well diffusion method.29 5 μg/mL of the test compounds were dissolved in 1 mL of DMSO solvent. Centrifuged pellets of bacteria from 24 h old culture containing approximately 104-106 colony forming unit (CFU) per mL was spread on the surface of Muller Hinton Agar (MHA) plates. Nutrient agar medium was prepared by suspended nutrient agar 28 g in 1 liter of distilled water, autoclaved and cooled to 45 °C, and then it was seeded with 15 mL of prepared inocula to have 106 CFU/mL. Petri dishes were prepared by pouring 10 mL of seeded nutrient agar. Wells were created in medium with the help of a sterile metallic borer and test solution was added. Experimental plates were incubated for 24 h at 37 °C............

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Abstract: The oxidation of D- Mannose with permanganate ion ( MnO4-) as oxidant was observed in acidic medium by visible spectrophotometric method in the temperature range (300 – 320) K. The reaction exihibit pseudo first oder kinetics with respect to change in concentration of D- Mannose, MNO4- and H+ followed by the change in absorbance of oxidant at 546 nm. Negligible effect of ionic strength ( μ ) on the rate of oxidation has also be noted which supports the presence of at least one neutral species in the rate determining step. The various activstion parameters have been calculated. A suitable mechanism consistent with experimental finding has been proposed.

Keywords: D-Mannose, Permanganate ion, first order, Iridium chloride and potassium nitrate

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Abstract: Potentially toxic trace elements such as lead when present in high levels in water, food and soil post serious human health threats all over the world. Adsorption process using different natural materials is among the most effective techniques for removing many heavy metal ions from different types of water sources. In this study, an attempt has been made to investigate the efficiency of groundnut shells for removing lead from aqueous solutions using batch mode technique. The equilibrium data of Pb (II) was analyzed using one one-parameter, six two-parameter and...........

Keywords: Adsorption, adsorbent,groundnut shell, isotherm, lead

[1]. M. M. Abood, J. Rajendiran, and N. N. Azhari, ―Agricultural waste as low cost adsorbent for the removal of Fe ( II ) ions from aqueous solution,‖ vol. 3, no. 1, pp. 29–39, 2015.
[2]. S. Babel and T. . T. A. Kurniawan, ―Cr(VI) removal from synthetic wastewater using coconut shell charcoal and commercial activated carbon modified with oxidizing agents and/or chitosan,‖ Chemo- Sph., vol. 54, no. 7, pp. 951–967, 2004.
[3]. C. Saka, O. ¨ mer Sahin, and M. M. Ku¨cu¨k, ―Applications on agricultural and forest waste adsorbents for the removal of lead ( II ) from contaminated waters,‖ pp. 379–394, 2012.
[4]. H. Lalhruaitluanga, K. Jayaram, M. N. V. Prasad, and K. K. Kumar, ―Lead (II) adsorption from aqueous solutions by raw and activated charcoals of Melocanna baccifera Roxburgh (bamboo)-A comparative study,‖ J. Hazard. Mater., vol. 175, pp. 311–318, 2010.
[5]. N. Azouaou, M. Belmedani, H. Mokaddem, and Z. Sadaoui, ―Adsorption of lead from aqueous solution onto untreated orange barks,‖ Chem. Eng. Trans., vol. 32, pp. 55–60, 2013..

Abstract: Cyclodextrins are cyclic oligo saccharides which have recently been recognized as useful pharmaceutical excipients. The molecular structure of these glucose derivatives generate a hydrophilic exterior surface and a non -polar cavity interior. Such cyclodextrin can interact with appropriate size drug molecules which lead to the formation of inclusion complexation. The aim of present investigation was to improve the solubility and ultimate bioavailability of Quinine sulphate and hydroxychloroquine sulphate, an antimalarial drug by encapsulating them in α-cyclodextrin. Effect of these complexes was studied by UV- VIS spectroscopy, Fluorescence spectroscopy, phase solubility study, FTIR spectroscopy. The water solubility of these drugs were increased by inclusion with α-CD according to phase solubility diagram. The results obtained from FTIR and 1HNMR spectroscopy confirmed the formation of inclusion complexation into α-cyclodextrin cavity

Keywords: Quinine sulphate, Hydroxychloroquinesulphate, cyclodextrins, inclusion complex

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